Reactome | Interaction of Tie2 and Dok-2

Interaction of Tie2 and Dok-2

Stable Identifier

R-HSA-204850

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Dok-2 is a member of a docking proteins class, termed the DOK family. The DOK family members are characterized by an N-terminal pleckstrin homology (PH) domain followed by a central PTB domain and a proline- and tyrosine-rich C-terminal tail. Dok-2 is recruited to activated Tie2 via its PTB domain, which results in its subsequent tyrosine phosphorylation, thereby establishing binding sites for the small GTPase-activating protein for Ras, p120RasGAP (RasGAP) and the adapter protein Nck. The binding of DOK to the receptor leads to Nck recruitment and subsequent phosphorylation. Binding of Pak to Nck follows. this brings about the Ang-1-dependent phosphorylation of Pak in endothelial cells.

Literature References

PubMed ID	Title	Journal	Year
9764820	The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R Dumont, DJ, Jones, N	Oncogene	1998
11689432	Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak Jones, J, Master, Z, Tran, J, Dumont, DJ, Kerbel, RS, Jones, N	EMBO J	2001