Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)

Stable Identifier
R-HSA-210977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
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Sos-1 bound to Grb2:Tie2 complex promotes the exchange of inactive Ras-GDP to active Ras-GTP (Boriack-Sjodin et al.1998, Khan et al. 2004).

Literature References
PubMed ID Title Journal Year
9690470 The structural basis of the activation of Ras by Sos

Boriack-Sjodin, PA, Margarit, SM, Kuriyan, J, Bar-Sagi, D

Nature 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of SOS-1 bound to Tie2:Grb2 [plasma membrane]

Physical Entity
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Bos taurus)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Caenorhabditis elegans)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Canis familiaris)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Danio rerio)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Drosophila melanogaster)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Gallus gallus)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Mus musculus)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Rattus norvegicus)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Sus scrofa)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Xenopus tropicalis)
Authored
Garapati, P V  (2008-03-05)
de Bono, B  (2008-03-05)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2008-01-18)
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