Sos-1 bound to Grb2:Tie2 complex promotes the exchange of inactive Ras-GDP to active Ras-GTP (Boriack-Sjodin et al.1998, Khan et al. 2004).
Boriack-Sjodin, PA, Margarit, SM, Bar-Sagi, D, Kuriyan, J
© 2021 Reactome