Sos-1 bound to Grb2:Tie2 complex promotes the exchange of inactive Ras-GDP to active Ras-GTP (Boriack-Sjodin et al.1998, Khan et al. 2004).
Boriack-Sjodin, PA, Margarit, SM, Kuriyan, J, Bar-Sagi, D
guanyl-nucleotide exchange factor activity of SOS-1 bound to Tie2:Grb2 [plasma membrane]
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