Reactome | Interaction of Tie2 and Ang4

Interaction of Tie2 and Ang4

Stable Identifier

R-HSA-204824

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Ang4 represents a third protein of the Ang family that binds to the Tie2 receptor. The mouse Ang3 and human Ang4 are interspecies orthologs. Ang4 acts as an activating ligand and induces phosphorylation in Tie2.

Literature References

PubMed ID	Title	Journal	Year
10051567	Angiopoietins 3 and 4: diverging gene counterparts in mice and humans Jenkins, NA, Yancopoulos, GD, Maisonpierre, PC, McClain, J, Zhou, H, Gilbert, DJ, Copeland, NG, Papadopoulos, N, Rojas, J, Huang, T, Jones, PF, Valenzuela, DM, Davis, S, Aldrich, TH, Griffiths, JA	Proc Natl Acad Sci U S A	1999
11969368	The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development Ward, NL, Dumont, DJ	Semin Cell Dev Biol	2002