Interaction of Tie2 and Ang4

Stable Identifier
R-HSA-204824
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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Interaction of Tie2 and Ang4
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Ang4 represents a third protein of the Ang family that binds to the Tie2 receptor. The mouse Ang3 and human Ang4 are interspecies orthologs. Ang4 acts as an activating ligand and induces phosphorylation in Tie2.

Literature References
PubMed ID Title Journal Year
10051567 Angiopoietins 3 and 4: diverging gene counterparts in mice and humans

Jenkins, NA, Yancopoulos, GD, Maisonpierre, PC, McClain, J, Zhou, H, Gilbert, DJ, Copeland, NG, Papadopoulos, N, Rojas, J, Huang, T, Jones, PF, Valenzuela, DM, Davis, S, Aldrich, TH, Griffiths, JA

Proc Natl Acad Sci U S A 1999
11969368 The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development

Ward, NL, Dumont, DJ

Semin Cell Dev Biol 2002
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as an event of
Orthologous Events
Interaction of Tie2 and Ang4 (Caenorhabditis elegans)
Interaction of Tie2 and Ang4 (Canis familiaris)
Interaction of Tie2 and Ang4 (Danio rerio)
Interaction of Tie2 and Ang4 (Drosophila melanogaster)
Interaction of Tie2 and Ang4 (Gallus gallus)
Interaction of Tie2 and Ang4 (Mus musculus)
Interaction of Tie2 and Ang4 (Rattus norvegicus)
Interaction of Tie2 and Ang4 (Sus scrofa)
Authored
Garapati, P V  (2008-03-05)
de Bono, B  (2008-03-05)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-12-03)
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