Reactome | Interaction of Tie2 and Grb14

Interaction of Tie2 and Grb14

Stable Identifier

R-HSA-204813

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Grb14 is also one of the signaling partners of Tie2. The SH2 domain of Grb2 mediates binding to Tie2. It binds residues Y816, Y1108 and Y1113 respectively, in the C-terminal tail region of Tie2/Tek.

Literature References

PubMed ID	Title	Journal	Year
10521483	Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. Jones, N, Master, Z, Jones, J, Bouchard, D, Gunji, Y, Sasaki, H, Daly, R, Alitalo, K, Dumont, DJ	J Biol Chem	1999
11607834	The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions Han, DC, Shen, TL, Guan, JL	Oncogene	2001