Reactome | Interaction of Tie2 and Grb2

Interaction of Tie2 and Grb2

Stable Identifier

R-HSA-204871

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Tie2/Tek provide mitogenic signals to endothelial cells by promoting the association of Grb2 to one of their phosphotyrosines. Grb2 is an adaptor protein that has been linked to activation of Ras and mitogen activated protein kinase (MAPK) cell growth signaling pathways. Grb2 also binds to the Y1102 of the kinase domain of Tie2 with one of its SH2 doamins.

Literature References

PubMed ID	Title	Journal	Year
10521483	Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. Alitalo, K, Daly, R, Bouchard, D, Jones, J, Master, Z, Sasaki, H, Gunji, Y, Dumont, DJ, Jones, N	J Biol Chem	1999
11191051	Tek/Tie2 signaling: new and old partners Dumont, DJ, Jones, N	Cancer Metastasis Rev	2000
7478529	GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase Peters, KG, Turck, CW, Huang, L, Rao, P	Oncogene	1995