Reactome | Interaction of Tie2 and p85 of PI3K

Interaction of Tie2 and p85 of PI3K

Stable Identifier

R-HSA-204798

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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The p85 subunit of phosphatidylinositol 3-kinase (PI3-kinase) associates with Tie2, most likely at phosphotyrosine 1102. This association leads on to the activation of Akt/PKB, a process linked to cell survival and antiapoptosis, and that may in part account for Tie2's role in vascular growth and maintenance.

Literature References

PubMed ID	Title	Journal	Year
10521483	Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. Alitalo, K, Daly, R, Bouchard, D, Jones, J, Master, Z, Sasaki, H, Gunji, Y, Dumont, DJ, Jones, N	J Biol Chem	1999
9632797	Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt Peters, KG, Blanar, MA, Meyer, T, Stauffer, TP, Huang, L, York, JD, Yang, WP, Kontos, CD	Mol Cell Biol	1998