Reactome | Interaction of Tie2 and Grb7

Interaction of Tie2 and Grb7

Stable Identifier

R-HSA-204773

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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Grb7 was initially identified as an EGF receptor binding protein and thereafter many binding partners have been reported. Grb7 interacts with Tie2/Tek in a phosphotyrosine-dependent manner through its SH2 domain.

Literature References

PubMed ID	Title	Journal	Year
11607834	The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions Han, DC, Shen, TL, Guan, JL	Oncogene	2001
10521483	Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. Jones, N, Master, Z, Jones, J, Bouchard, D, Gunji, Y, Sasaki, H, Daly, R, Alitalo, K, Dumont, DJ	J Biol Chem	1999