Reactome | Interaction of Tie2 with Ang1

Interaction of Tie2 with Ang1

Stable Identifier

R-HSA-204779

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Tie receptors and their angiopoietin ligands play a critical role in angiogenesis or blood vessel formation. They are considered to control numerous signaling pathways that are involved in diverse cellular processes, such as cell migration, proliferation, survival and reorganization of the actin cytoskeleton.

Tie (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains) represents a class of receptor tyrosine kinases (RTKs) that are predominately expressed by vascular endothelial cells. The angiopoietins are a family of growth factors that are largely specific for endothelium and they bind to Tie2/Tek RTKs.

Tie2 signaling initially involves the activation of Tie2 by the interaction of angiopoietin 1. Angiopoietin interacts with the Tie2 receptor with its fibrinogen like domain (FLD). This interaction leads to the dimerization of both the receptor and the ligand, and later initiate the trans-phosphorylation of Tie2.

Literature References

PubMed ID	Title	Journal	Year
11447223	Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region Xu, Y, Yu, Q	J Biol Chem	2001
11566266	Angiopoietin and Tie signaling pathways in vascular development Loughna, S, Sato, TN	Matrix Biol	2001
11969368	The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development Ward, NL, Dumont, DJ	Semin Cell Dev Biol	2002
8980223	Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning Davis, S, Aldrich, TH, Jones, PF, Acheson, A, Compton, DL, Jain, V, Ryan, TE, Bruno, J, Radziejewski, C, Maisonpierre, PC, Yancopoulos, GD	Cell	1996