Reactome | RBBP8 [nucleoplasm]

RBBP8 [nucleoplasm]

Stable Identifier

R-HSA-912399

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RBBP8/CtIP, Retinoblastoma-binding protein 8, RBBP8_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99708 RBBP8

Gene Names

RBBP8, CTIP

Chain

chain:1-897

Reference Genes

BioGPS Gene:5932 RBBP8

COSMIC (genes):RBBP8 RBBP8

CTD Gene:5932 RBBP8

dbSNP Gene:5932 RBBP8

ENSEMBL:ENSG00000101773 RBBP8

ENSEMBL_homo_sapiens_GENE:ENSG00000101773.19 RBBP8

HGNC:9891 RBBP8

KEGG Gene (Homo sapiens):5932 RBBP8

Monarch:5932 RBBP8

NCBI Gene:5932 RBBP8

OMIM:604124 RBBP8

UCSC:Q99708 RBBP8

Reference Transcript

Other Identifiers

11727547_s_at

16851397

203344_PM_s_at

203344_s_at

35227_at

3781451

3781452

3781453

3781454

3781455

3781456

3781457

3781458

3781461

3781462

3781463

3781465

3781466

3781470

3781474

3781476

3781477

3781479

3781480

3781482

3781483

3781484

3781485

3781486

3781487

3781489

3781490

3781491

3781494

3781496

3781498

3781499

3781502

3781503

3781504

3781505

5932

8020468

A_14_P115784

A_23_P252371

A_33_P3240702

GE59378

GO:0000014

GO:0000082

GO:0000278

GO:0000724

GO:0001835

GO:0003677

GO:0003684

GO:0003714

GO:0003824

GO:0004518

GO:0004519

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006260

GO:0006281

GO:0006310

GO:0006351

GO:0006355

GO:0006357

GO:0006974

GO:0007049

GO:0010792

GO:0016787

GO:0017053

GO:0022414

GO:0023052

GO:0035825

GO:0042802

GO:0043226

GO:0043231

GO:0044818

GO:0045892

GO:0046872

GO:0048856

GO:0051301

GO:0051321

GO:0061629

GO:0070533

GO:0110025

GO:0140097

GO:0140110

HMNXSV003003764

ILMN_1678695

ILMN_1739101

ILMN_2363621

PH_hs_0025587

TC18000097.hg

U72066_at

g4506440_3p_a_at

Participates

as a component of

as an output of

RBBP8 gene expression is inhibited by E2F6 (Homo sapiens)

Other forms of this molecule

p-S327,T847-RBBP8 [nucleoplasm]

Ac-K-RBBP8 [nucleoplasm]

p-S327,T847,T859-RBBP8 [nucleoplasm]

Inferred To

Rbbp8 [nucleoplasm] (Mus musculus)

Rbbp8 [nucleoplasm] (Rattus norvegicus)

RBBP8 [nucleoplasm] (Bos taurus)

RBBP8 [nucleoplasm] (Canis familiaris)

RBBP8 [nucleoplasm] (Gallus gallus)

RBBP8 [nucleoplasm] (Sus scrofa)

rbbp8 [nucleoplasm] (Danio rerio)

rbbp8 [nucleoplasm] (Xenopus tropicalis)

com-1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of RBBP8 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of RBBP8 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_006722583.1, NP_976037.1, XP_011524434.1, NP_002885.1, XP_006722582.1, XP_006722584.1, NP_976036.1

OpenTargets

ENSG00000101773

HPA

ENSG00000101773-RBBP8

GeneCards

Q99708

Ensembl

ENST00000327155, ENSP00000382630, ENST00000399722, ENSP00000323050, ENSP00000382628, ENST00000399725, ENSG00000101773

PRO

Q99708

Pharos - Targets

Q99708

Orphanet

20823

PDB

1Y98, 2L4Z, 7BGF, 4D2H

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.935	15
UniProt:Q13363 CTBP1	3	monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) CTBP1 [nucleoplasm] (R-HSA-212372)	0.691	4
UniProt:P49959 MRE11	2	MRE11A [nucleoplasm] (R-HSA-59544) MRE11A [cytosol] (R-HSA-3204309)	0.669	3
UniProt:Q9UQ84 EXO1	1	EXO1 [nucleoplasm] (R-HSA-5357514)	0.656	4
UniProt:Q99708 RBBP8	4	p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399) Ac-K-RBBP8 [nucleoplasm] (R-HSA-5685955) p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138)	0.65	4
UniProt:O75475 PSIP1	2	PSIP1 [nucleoplasm] (R-HSA-3008841) PSIP1 [cytosol] (R-HSA-3008840)	0.602	4
UniProt:O60934 NBN	3	p-S343-NBN [nucleoplasm] (R-HSA-75237) NBN [cytosol] (R-HSA-5684005) NBN [nucleoplasm] (R-HSA-75163)	0.564	2
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.564	2
UniProt:P48059 LIMS1	1	LIMS1 [cytosol] (R-HSA-432859)	0.553	2
UniProt:P56545 CTBP2	1	CTBP2 [nucleoplasm] (R-HSA-5333990)	0.547	2
UniProt:Q9BS26 ERP44	2	ERP44 [extracellular region] (R-HSA-6806302) ERP44 [specific granule lumen] (R-HSA-6799567)	0.527	2
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.508	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.508	3
UniProt:Q9NVH0 EXD2			0.499	3