NRAGE sequesters CHE1 in the cytoplasm

Stable Identifier
R-HSA-204958
Type
Reaction [binding]
Species
Homo sapiens
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CHE1, also named AATF, is an Apoptosis Antagonizing Transcription Factor in cortical neurons. NRAGE binds to CHE1, inhibiting its nuclear localization by sequestering it in the cytoplasm, and, consequently, antagonizes its anti-apoptotic function.

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