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MECP2 binds LBR
Stable Identifier
R-HSA-9018594
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
,
nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
Regulation of MECP2 expression and activity (Homo sapiens)
MECP2 binds LBR (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MECP2 and lamin B receptor (LBR) associate at the inner side of the nuclear envelope. The interaction involves the linker region of MECP2 and appears to happen in heterochromatin regions at the nuclear periphery (Guarda et al. 2009).
Literature References
PubMed ID
Title
Journal
Year
19331822
Interaction between the inner nuclear membrane lamin B receptor and the heterochromatic methyl binding protein, MeCP2
Bolognese, F
,
Guarda, A
,
Badaracco, G
,
Bonapace, IM
Exp. Cell Res.
2009
Participants
Input
LBR [nuclear envelope]
(Homo sapiens)
MECP2 [nucleoplasm]
(Homo sapiens)
Output
MECP2:LBR [nuclear envelope]
(Homo sapiens)
Participates
as an event of
Regulation of MECP2 expression and activity (Homo sapiens)
Orthologous Events
MECP2 binds LBR (Bos taurus)
MECP2 binds LBR (Canis familiaris)
MECP2 binds LBR (Danio rerio)
MECP2 binds LBR (Mus musculus)
MECP2 binds LBR (Rattus norvegicus)
MECP2 binds LBR (Sus scrofa)
MECP2 binds LBR (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2017-10-02)
Reviewed
Krishnaraj, R (2018-08-07)
Christodoulou, J (2018-08-07)
Created
Orlic-Milacic, M (2017-09-01)
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