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EIF4A2 [cytosol]
Stable Identifier
R-HSA-72575
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF4A-II, eIF4AII, eIF-4A-II, eukaryotic initiation factor 4A-II, Eukaryotic initiation factor 4A-II
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
M-decay: degradation of maternal mRNAs by maternally stored factors (Homo sapiens)
BTG4 binds CNOT7 of the CCR4-NOT complex, PABPN1L, and eIF4E of the mRNP (Homo sapiens)
CCR4-NOT:BTG4:PABPN1L:mRNP [cytosol] (Homo sapiens)
mRNP regulated by BTG4 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
mRNP regulated by BTG4 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP (Homo sapiens)
CCR4-NOT:BTG4:PABPN1L:deadenylated mRNP [cytosol] (Homo sapiens)
deadenylated mRNP regulated by BTG4 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
CCR4-NOT:BTG4:PABPN1L:mRNP [cytosol] (Homo sapiens)
mRNP regulated by BTG4 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Z-decay: degradation of maternal mRNAs by zygotically expressed factors (Homo sapiens)
DIS3L2 binds PABPN1 in PABPN1:uridylated mRNA complex (Homo sapiens)
DIS3L2:PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
DIS3L2 hydrolyzes uridylated mRNA (Homo sapiens)
DIS3L2:PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
PABPN1 binds oligouridylated mRNA (Homo sapiens)
PABPN1:uridylated partially deadenylated mRNA complex [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
TUT4,TUT7 oligouridylate mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)
EIF4F [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
eIF4F:mRNA [cytosol] (Homo sapiens)
EIF4F [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
Deadenylation of mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Translatable mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
PARN deadenylates mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
TUT4,TUT7 oligouridylate mRNA (Homo sapiens)
Partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Homo sapiens)
eIF4A [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Cap-bound mRNA is activated by helicases (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Formation of the cap-binding eIF4F complex (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
eIF4F binds to mRNP (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4A2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14240 EIF4A2
Gene Names
EIF4A2, DDX2B, EIF4F
Chain
chain:1-407
Reference Genes
BioGPS Gene:1974 EIF4A2
COSMIC (genes):EIF4A2 EIF4A2
CTD Gene:1974 EIF4A2
dbSNP Gene:1974 EIF4A2
ENSEMBL:ENSG00000156976 EIF4A2
ENSEMBL_homo_sapiens_GENE:ENSG00000156976.17 EIF4A2
HGNC:3284 EIF4A2
KEGG Gene (Homo sapiens):1974 EIF4A2
Monarch:1974 EIF4A2
NCBI Gene:1974 EIF4A2
OMIM:601102 EIF4A2
UCSC:Q14240 EIF4A2
Reference Transcript
RefSeq:NM_001967.3 EIF4A2
Other Identifiers
11726977_s_at
1420_s_at
1974
200912_PM_s_at
200912_s_at
2656751
2656756
2656759
2656761
2656768
2656770
2656774
2656775
2656777
2656781
2656784
2656788
2656789
2656790
2656791
2656792
4008953
4008957
8084694
A_14_P125598
A_23_P121250
D30655_at
GE81095
GO:0000166
GO:0002181
GO:0002183
GO:0003676
GO:0003723
GO:0003724
GO:0003743
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005829
GO:0006412
GO:0006413
GO:0006446
GO:0016281
GO:0016787
GO:0016887
GO:0045182
GO:0048471
GO:0140098
GO:0140657
GO:1900260
GO:1990830
HMNXSV003035497
ILMN_1685722
PH_hs_0030638
g9945313_3p_a_at
Participates
as a component of
eIF4A subunits complex [cytosol] (Homo sapiens)
as a member of
eIF4A [cytosol] (Homo sapiens)
Inferred To
Homologues of EIF4A2 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of EIF4A2 [cytosol]
(Bos taurus)
Ghost homologue of EIF4A2 [cytosol]
(Danio rerio)
Ghost homologue of EIF4A2 [cytosol]
(Sus scrofa)
Ghost homologue of EIF4A2 [cytosol]
(Xenopus tropicalis)
EIF4A2 [cytosol]
(Caenorhabditis elegans)
EIF4A2 [cytosol]
(Canis familiaris)
EIF4A2 [cytosol]
(Drosophila melanogaster)
EIF4A2 [cytosol]
(Gallus gallus)
EIF4A2 [cytosol]
(Mus musculus)
EIF4A2 [cytosol]
(Plasmodium falciparum)
EIF4A2 [cytosol]
(Rattus norvegicus)
EIF4A2 [cytosol]
(Saccharomyces cerevisiae)
EIF4A2 [cytosol]
(Schizosaccharomyces pombe)
ifdA [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001958.2
OpenTargets
ENSG00000156976
HPA
ENSG00000156976-EIF4A2
GeneCards
Q14240
Ensembl
ENSP00000398370
,
ENST00000440191
,
ENSG00000156976
,
ENST00000323963
,
ENSP00000326381
PRO
Q14240
Pharos - Targets
Q14240
HMDB Protein
HMDBP11794
PDB
3BOR
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q53EL6 PDCD4
1
PDCD4 [cytosol]
(R-HSA-5432887)
0.675
6
UniProt:Q04637 EIF4G1
2
p-S1108,S1148,S1192-EIF4G1 [cytosol]
(R-HSA-165762)
EIF4G1 [cytosol]
(R-HSA-72584)
0.656
4
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.564
2
UniProt:Q7L190 DPPA4
1
DPPA4 [nucleoplasm]
(R-HSA-452999)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.508
2
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