Phosphorylation and activation of eIF4G by activated S6K1

Stable Identifier
R-HSA-165766
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated S6K1 in turn phosphorylates eIF4G, a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.

Literature References
PubMed ID Title Journal Year
15314020 Upstream and downstream of mTOR

Hay, N, Sonenberg, N

Genes Dev 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
kinase activity of p-S371,T389-RPS6KB1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created