Phosphorylation and activation of eIF4G by activated S6K1

Stable Identifier
R-HSA-165766
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylated S6K1 in turn phosphorylates eIF4G, a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.

Literature References
PubMed ID Title Journal Year
15314020 Upstream and downstream of mTOR

Hay, N, Sonenberg, N

Genes Dev 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
kinase activity of p-S371,T389-RPS6KB1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed