Phosphorylation and activation of eIF4G by activated S6K1

Stable Identifier
R-HSA-165766
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Summation

Phosphorylated S6K1 in turn phosphorylates eIF4G, a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.

Literature References
PubMed ID Title Journal Year
15314020 Upstream and downstream of mTOR

Hay, N, Sonenberg, N

Genes Dev 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
kinase activity of p-S371,T389-RPS6KB1 [cytosol]
Physical Entity
p-S371,T389-RPS6KB1 [cytosol]
Activity
kinase activity (0016301)
Orthologous Events
Phosphorylation and activation of eIF4G by activated S6K1 (Arabidopsis thaliana)
Phosphorylation and activation of eIF4G by activated S6K1 (Bos taurus)
Phosphorylation and activation of eIF4G by activated S6K1 (Caenorhabditis elegans)
Phosphorylation and activation of eIF4G by activated S6K1 (Canis familiaris)
Phosphorylation and activation of eIF4G by activated S6K1 (Danio rerio)
Phosphorylation and activation of eIF4G by activated S6K1 (Drosophila melanogaster)
Phosphorylation and activation of eIF4G by activated S6K1 (Gallus gallus)
Phosphorylation and activation of eIF4G by activated S6K1 (Mus musculus)
Phosphorylation and activation of eIF4G by activated S6K1 (Oryza sativa)
Phosphorylation and activation of eIF4G by activated S6K1 (Rattus norvegicus)
Phosphorylation and activation of eIF4G by activated S6K1 (Saccharomyces cerevisiae)
Phosphorylation and activation of eIF4G by activated S6K1 (Sus scrofa)
Phosphorylation and activation of eIF4G by activated S6K1 (Taeniopygia guttata)
Phosphorylation and activation of eIF4G by activated S6K1 (Xenopus tropicalis)
Authored
Jupe, S  (2015-01-23)
Reviewed
Zwartkruis, FJ  (2015-05-14)