Reactome | TACR1 [plasma membrane]

TACR1 [plasma membrane]

Stable Identifier

R-HSA-380103

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Substance P receptor, NK1R_HUMAN, NK1 receptor

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
      - ARRB bind GPCRs (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        TACR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25103 TACR1

Gene Names

TACR1, NK1R, TAC1R

Chain

chain:1-407

Reference Genes

BioGPS Gene:6869 TACR1

COSMIC (genes):TACR1 TACR1

CTD Gene:6869 TACR1

dbSNP Gene:6869 TACR1

ENSEMBL:ENSG00000115353 TACR1

HGNC:11526 TACR1

KEGG Gene (Homo sapiens):6869 TACR1

Monarch:6869 TACR1

NCBI Gene:6869 TACR1

OMIM:162323 TACR1

UCSC:P25103 TACR1

Reference Transcript

Other Identifiers

0000460609

0003710671

0006650722

11730122_at

11730123_a_at

16899401

208048_at

208049_s_at

210637_at

230908_at

2560525

2560526

2560527

2560528

2560529

2560549

2560574

2560575

2560576

2560577

2560578

2560579

2560580

2560581

2KS9

2KSA

2KSB

35077_at

47806_at

6869

6E59

6HLL

6HLO

6HLP

74573

8053266

A_24_P148590

AAA36641

AAA36644

AAA59933

AAA59936

AAA60601

AAB20168

AAH74911

AAH74912

AAR23925

AC007400

AK289765

AY462098

BAF82454

BC074911

BC074912

CAA46292

CCDS1958

CCDS46345

CH471053

EAW99596

ENSG00000115353

ENSP00000303522

ENSP00000386448

ENST00000305249

ENST00000305249.9

ENST00000409848

ENST00000409848.3

EntrezGene:6869

EntrezGene:TACR1

g189213_3p_at

g7669545_3p_a_at

g7669545_3p_at

GE58067

GE698210

GO:0000003

GO:0003674

GO:0004930

GO:0004995

GO:0005515

GO:0005575

GO:0005623

GO:0005886

GO:0005887

GO:0005929

GO:0006950

GO:0006954

GO:0007165

GO:0007186

GO:0007200

GO:0007204

GO:0007217

GO:0008150

GO:0009582

GO:0016020

GO:0016021

GO:0016496

GO:0036126

GO:0040011

GO:0042592

GO:0043226

GO:0048265

GO:0048870

GO:0061827

GO:0070472

GO:0071944

GO:0097225

GO:1902093

HGNC:11526

HPA074573

Hs.66072.0.A1_3p_at

ILMN_1680330

ILMN_1747883

ILMN_1786239

IPR000046

IPR000276

IPR001681

IPR017452

M74290

M74290_at

M76675

M81797

M84425

M84426

MIM:162323

NM_001058

NM_015727

NP_001049

NP_056542

PF00001

PH_hs_0000142

PR00237

PR00244

PR01024

S62045

TACR1

TACR1-201

TACR1-202

TC02002005.hg

UPI000002AF31

UPI0000039D68

X65177

X65178

X65179

X65180

X65181

Participant Of

hasCandidate

ARRB-binding GPCRs [plasma membrane]

input

Tachykinin receptor 1 (NK1) binds to substance P

hasMember

GPCRs that activate Gq/11 [plasma membrane]

hasComponent

TACR1:TAC1(58-68) [plasma membrane]

Other forms of this molecule

TACR1 [clathrin-coated endocytic vesicle membrane]

Inferred To

TACR1 [plasma membrane] (Bos taurus)

TACR1 [plasma membrane] (Caenorhabditis elegans)

TACR1 [plasma membrane] (Danio rerio)

TACR1 [plasma membrane] (Mus musculus)

TACR1 [plasma membrane] (Rattus norvegicus)

TACR1 [plasma membrane] (Sus scrofa)

TACR1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001049.1, NP_056542.1

ZINC - World Drugs

NK1R_HUMAN

OpenTargets

ENSG00000115353

ZINC - FDA approved

NK1R_HUMAN

ZINC - Substances

NK1R_HUMAN

ZINC - Biogenic

NK1R_HUMAN

ZINC target

P25103

PRO

P25103

PDB

6HLP, 2KSA, 6E59, 6HLL, 6HLO, 2KS9, 2KSB

ZINC - Investigational

NK1R_HUMAN

GeneCards

P25103

ZINC - Predictions - Purchasable

NK1R_HUMAN

Orphanet

25751

HMDB Protein

HMDBP07842

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P0B6 CC167			0.488	2
UniProt:Q9BVK8 TM147			0.488	2