Reactome | PPP1R8 [nucleoplasm]

PPP1R8 [nucleoplasm]

Stable Identifier

R-HSA-9770253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear inhibitor of protein phosphatase 1, PP1R8_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q12972 PPP1R8

Gene Names

PPP1R8, ARD1, NIPP1

Chain

chain:1-351

Reference Genes

BioGPS Gene:5511 PPP1R8

COSMIC - genes:PPP1R8 PPP1R8

CTD Gene:5511 PPP1R8

dbSNP Gene:5511 PPP1R8

ENSEMBL:ENSG00000117751 PPP1R8

HGNC:9296 PPP1R8

KEGG:hsa:5511 PPP1R8

Monarch:5511 PPP1R8

NCBI Gene:5511 PPP1R8

OMIM:602636 PPP1R8

UCSC:Q12972 PPP1R8

Reference Transcript

Participates

as a component of

as an input of

Formation of the Spliceosomal A complex (Homo sapiens)

as an output of

Formation of the Spliceosomal Pre-B complex (Homo sapiens)

Inferred To

NiPp1 [nucleoplasm] (Drosophila melanogaster)

ppp1r8 [nucleoplasm] (Xenopus tropicalis)

PPP1R8 [nucleoplasm] (Bos taurus)

PPP1R8 [nucleoplasm] (Canis familiaris)

PPP1R8 [nucleoplasm] (Gallus gallus)

PPP1R8 [nucleoplasm] (Rattus norvegicus)

PPP1R8 [nucleoplasm] (Sus scrofa)

Ppp1r8 [nucleoplasm] (Mus musculus)

Ghost homologue of PPP1R8 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of PPP1R8 [nucleoplasm] (Schizosaccharomyces pombe)

ppp1r8b [nucleoplasm] (Danio rerio)

sut-6 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002704.1, NP_054829.2, NP_612568.1

ENSEMBL

ENST00000236412, ENSP00000236412, ENSP00000311677, ENST00000311772, ENSP00000363042, ENST00000373931, ENSG00000117751

OpenTargets

ENSG00000117751

GeneCards

PPP1R8

HPA

ENSG00000117751-PPP1R8

PRO

Q12972

Pharos - Targets

Q12972

GlyGen

Q12972

HMDB Protein

HMDBP08791

PDB

3V4Y

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62136 PPP1CA	2	PPP1CA [cytosol] (R-HSA-163525) PPP1CA [nucleoplasm] (R-HSA-61995)	0.913	10
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.816	6
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.802	8
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	3
UniProt:Q92624 APBP2			0.556	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.508	2