Reactome | PPP1R8 [nucleoplasm]

PPP1R8 [nucleoplasm]

Stable Identifier

R-HSA-9770253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear inhibitor of protein phosphatase 1, PP1R8_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q12972 PPP1R8

Gene Names

PPP1R8, ARD1, NIPP1

Chain

chain:1-351

Reference Genes

BioGPS Gene:5511 PPP1R8

COSMIC (genes):PPP1R8 PPP1R8

CTD Gene:5511 PPP1R8

dbSNP Gene:5511 PPP1R8

ENSEMBL:ENSG00000117751 PPP1R8

ENSEMBL_homo_sapiens_GENE:ENSG00000117751.18 PPP1R8

HGNC:9296 PPP1R8

KEGG Gene (Homo sapiens):5511 PPP1R8

Monarch:5511 PPP1R8

NCBI Gene:5511 PPP1R8

OMIM:602636 PPP1R8

UCSC:Q12972 PPP1R8

Reference Transcript

Other Identifiers

11730734_a_at

11730735_s_at

11730736_a_at

11735146_a_at

16661477

207830_PM_s_at

207830_s_at

2327260

2327261

2327262

2327263

2327264

2327267

2327268

2327271

2327272

2327276

2327277

2327278

2327279

2327280

2327281

2327282

37705_at

5511

7899377

A_14_P114015

A_23_P12272

A_24_P139773

GE58952

GE79738

GO:0003677

GO:0003723

GO:0003729

GO:0003824

GO:0004518

GO:0004519

GO:0004864

GO:0004865

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0006397

GO:0006401

GO:0008283

GO:0008380

GO:0008995

GO:0016071

GO:0016607

GO:0016787

GO:0019888

GO:0035308

GO:0036211

GO:0043226

GO:0098772

GO:0140098

GO:0140678

HMNXSV003013898

ILMN_1732141

ILMN_1781526

ILMN_2321485

PH_hs_0017296

TC01000370.hg

U14575_at

g4506014_3p_s_at

Participates

as an input of

Formation of the Spliceosomal A complex (Homo sapiens)

as an output of

Formation of the Spliceosomal Pre-B complex (Homo sapiens)

as a component of

Spliceosomal A complex [nucleoplasm] (Homo sapiens)

Inferred To

NiPp1 [nucleoplasm] (Drosophila melanogaster)

ppp1r8 [nucleoplasm] (Xenopus tropicalis)

PPP1R8 [nucleoplasm] (Bos taurus)

PPP1R8 [nucleoplasm] (Canis familiaris)

PPP1R8 [nucleoplasm] (Gallus gallus)

PPP1R8 [nucleoplasm] (Rattus norvegicus)

PPP1R8 [nucleoplasm] (Sus scrofa)

Ppp1r8 [nucleoplasm] (Mus musculus)

Ghost homologue of PPP1R8 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of PPP1R8 [nucleoplasm] (Schizosaccharomyces pombe)

sut-6 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002704.1, XP_016857083.1, NP_612568.1, NP_054829.2

OpenTargets

ENSG00000117751

HPA

ENSG00000117751-PPP1R8

GeneCards

Q12972

Ensembl

ENST00000373931, ENSP00000311677, ENSG00000117751, ENST00000311772, ENSP00000363042, ENSP00000236412, ENST00000236412

PRO

Q12972

Pharos - Targets

Q12972

PDB

3V4Y

HMDB Protein

HMDBP08791

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.913	10
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.816	6
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.745	7
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	3
UniProt:Q92624 APBP2			0.556	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.508	2

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