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PPP1CB, PPP1CB [cytosol]
Stable Identifier
R-HSA-9660304
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by MRAS-complex mutants (Homo sapiens)
Gain-of-function MRAS complexes activate RAF signaling (Homo sapiens)
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
mutant MRAS:SHOC2:PP1 complexes [plasma membrane] (Homo sapiens)
S-GCC MRAS mutants:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2 S2G:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
SHOC2 M1731 mutant abolishes MRAS complex function (Homo sapiens)
SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
SHOC2 M173I:MRAS:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAF activation (Homo sapiens)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
Participants
members
PPP1CB [cytosol]
(Homo sapiens)
PPP1CC [cytosol]
(Homo sapiens)
Participates
as a component of
S-GCC MRAS:GTP:SHOC2 S2G:PP1 [plasma membrane] (Homo sapiens)
S-GCC MRAS mutants:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
SHOC2 M173I:MRAS:PP1 [plasma membrane] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
Inferred To
PPP1CB, PPP1CB [cytosol]
(Bos taurus)
PPP1CB, PPP1CB [cytosol]
(Caenorhabditis elegans)
PPP1CB, PPP1CB [cytosol]
(Gallus gallus)
PPP1CB, PPP1CB [cytosol]
(Mus musculus)
PPP1CB, PPP1CB [cytosol]
(Rattus norvegicus)
PPP1CB, PPP1CB [cytosol]
(Sus scrofa)
ppp1cbl [cytosol]
(Danio rerio)
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