Reactome | RIF1 [nucleoplasm]

RIF1 [nucleoplasm]

Stable Identifier

R-HSA-480742

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Telomere-associated protein RIF1, RIF1_HUMAN

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Nonhomologous End-Joining (NHEJ) (Homo sapiens)
    - Activated ATM phosphorylates DCLRE1C (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)
    - Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)
      - RIF1 [nucleoplasm] (Homo sapiens)
    - RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)
      - RIF1 [nucleoplasm] (Homo sapiens)
    - TP53BP1 recruits DCLRE1C to ATM (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5UIP0 RIF1

Gene Names

RIF1

Chain

chain:1-2472

Reference Genes

BioGPS Gene:55183 RIF1

COSMIC (genes):RIF1 RIF1

CTD Gene:55183 RIF1

dbSNP Gene:55183 RIF1

ENSEMBL:ENSG00000080345 RIF1

HGNC:23207 RIF1

KEGG:hsa:55183 RIF1

Monarch:55183 RIF1

NCBI Gene:55183 RIF1

OMIM:608952 RIF1

UCSC:Q5UIP0 RIF1

Reference Transcript

Participates

as an output of

Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)

as an input of

RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)

as a component of

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)

Inferred To

rif1 [nucleoplasm] (Danio rerio)

rif1 [nucleoplasm] (Schizosaccharomyces pombe)

rif1 [nucleoplasm] (Xenopus tropicalis)

RIF1 [nucleoplasm] (Bos taurus)

RIF1 [nucleoplasm] (Canis familiaris)

RIF1 [nucleoplasm] (Dictyostelium discoideum)

RIF1 [nucleoplasm] (Gallus gallus)

RIF1 [nucleoplasm] (Saccharomyces cerevisiae)

RIF1 [nucleoplasm] (Sus scrofa)

Rif1 [nucleoplasm] (Drosophila melanogaster)

Rif1 [nucleoplasm] (Mus musculus)

Rif1 [nucleoplasm] (Rattus norvegicus)

rif-1.1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000444746, ENSP00000416123, ENST00000430328, ENST00000428287, ENST00000243326, ENSP00000415691, ENSP00000243326, ENSG00000080345, ENSP00000414615, ENSP00000390181, ENST00000453091

OpenTargets

ENSG00000080345

GeneCards

RIF1

HPA

ENSG00000080345-RIF1

PRO

Q5UIP0

Pharos - Targets

Q5UIP0

GlyGen

Q5UIP0

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.813	6
UniProt:P54132 BLM	2	BLM [nucleoplasm] (R-HSA-174881) 4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883)	0.74	8
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.676	4
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.671	6
UniProt:P36873-1 PPP1CC			0.547	2
UniProt:P15927 RPA2	2	RPA2 [nucleoplasm] (R-HSA-68457) p-S33-RPA2 [nucleoplasm] (R-HSA-5685148)	0.547	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.527	3
UniProt:Q15435 PP1R7			0.508	2
UniProt:Q9H9A7 RMI1	1	RMI1 [nucleoplasm] (R-HSA-5685949)	0.462	4
UniProt:Q13472 TOP3A	2	TOP3A [mitochondrial matrix] (R-HSA-9914882) TOP3A [nucleoplasm] (R-HSA-912452)	0.462	3