Reactome | RIF1 [nucleoplasm]

RIF1 [nucleoplasm]

Stable Identifier

R-HSA-480742

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Telomere-associated protein RIF1, RIF1_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Nonhomologous End-Joining (NHEJ) (Homo sapiens)
    - Activated ATM phosphorylates DCLRE1C (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)
    - Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)
      - RIF1 [nucleoplasm] (Homo sapiens)
    - RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)
      - RIF1 [nucleoplasm] (Homo sapiens)
    - TP53BP1 recruits DCLRE1C to ATM (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Homo sapiens)
        
        RIF1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5UIP0 RIF1

Gene Names

RIF1

Chain

chain:1-2472

Reference Genes

BioGPS Gene:55183 RIF1

COSMIC (genes):RIF1 RIF1

CTD Gene:55183 RIF1

dbSNP Gene:55183 RIF1

ENSEMBL:ENSG00000080345 RIF1

HGNC:23207 RIF1

KEGG Gene (Homo sapiens):55183 RIF1

Monarch:55183 RIF1

NCBI Gene:55183 RIF1

OMIM:608952 RIF1

UCSC:Q5UIP0 RIF1

Reference Transcript

Other Identifiers

0004850609

11731683_a_at

11731684_at

11731685_s_at

11731686_x_at

11745224_a_at

11752738_a_at

11759068_at

16886503

214700_x_at

226503_at

226821_at

236620_at

240098_at

241820_at

2510486

2510487

2510488

2510489

2510490

2510492

2510493

2510494

2510495

2510499

2510501

2510502

2510504

2510506

2510507

2510508

2510509

2510510

2510511

2510514

2510517

2510519

2510520

2510523

2510524

2510525

2510527

2510529

2510530

2510531

2510533

2510534

2510535

2510536

2510537

2510538

2510539

2510540

2510541

2510542

2510543

2510545

2510546

2510547

2510548

2510549

2510550

2510551

2510552

2510553

2510554

2510555

2510556

2510557

2510558

2510559

2510560

2510561

2510562

2510563

2510564

32954_at

46563_at

53659_r_at

54867_at

55183

65415_s_at

78588_at

8045697

A_23_P382302

A_23_P5611

A_24_P34476

GE56515

GE80205

GE88669

GO:0000122

GO:0000228

GO:0000723

GO:0000781

GO:0000790

GO:0000793

GO:0001939

GO:0001940

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005819

GO:0005856

GO:0005886

GO:0006259

GO:0006281

GO:0006303

GO:0006348

GO:0006464

GO:0006950

GO:0006974

GO:0007049

GO:0008150

GO:0009058

GO:0016604

GO:0019827

GO:0031965

GO:0034641

GO:0035861

GO:0042592

GO:0043226

GO:0043247

GO:0045830

GO:0048856

GO:0051233

GO:0051276

GO:0051574

GO:1990830

GO:2000042

GO:2001034

Hs.134724.0.A1_3p_at

Hs.19150.0.S1_3p_at

Hs.225841.0.S1_3p_at

Hs.225841.1.S1_3p_a_at

Hs.254020.0.A1_3p_at

Hs.254020.1.S1_3p_at

ILMN_1755758

ILMN_2149053

PH_hs_0040594

TC02000939.hg

TC02003637.hg

U79263_at

Participant Of

input

RIF1 and PAX1IP bind TP53BP1 at DNA DSBs

output

Association of Ku heterodimer with ends of DNA double-strand break

hasComponent

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm]

Inferred To

rif1 [nucleoplasm] (Danio rerio)

rif1 [nucleoplasm] (Schizosaccharomyces pombe)

RIF1 [nucleoplasm] (Caenorhabditis elegans)

RIF1 [nucleoplasm] (Canis familiaris)

RIF1 [nucleoplasm] (Dictyostelium discoideum)

RIF1 [nucleoplasm] (Gallus gallus)

RIF1 [nucleoplasm] (Saccharomyces cerevisiae)

RIF1 [nucleoplasm] (Sus scrofa)

Rif1 [nucleoplasm] (Drosophila melanogaster)

Rif1 [nucleoplasm] (Mus musculus)

Rif1 [nucleoplasm] (Rattus norvegicus)

gpr89b [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001171135.1, NP_060621.3, XP_005246722.1, NP_001171136.1, NP_001171134.1

OpenTargets

ENSG00000080345

HPA

ENSG00000080345-RIF1

GeneCards

Q5UIP0

Ensembl

ENSP00000390181, ENSP00000416123, ENSP00000415691, ENST00000243326, ENSG00000080345, ENSP00000243326, ENST00000453091, ENST00000428287, ENSP00000414615, ENST00000430328, ENST00000444746

PRO

Q5UIP0

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.765	5
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.69	4
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.597	3
UniProt:P54132 BLM	2	BLM [nucleoplasm] (R-HSA-174881) 4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883)	0.565	6
UniProt:P15927 RPA2	2	p-S33-RPA2 [nucleoplasm] (R-HSA-5685148) RPA2 [nucleoplasm] (R-HSA-68457)	0.547	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q15435 PP1R7			0.508	2
UniProt:Q13472 TOP3A	1	TOP3A [nucleoplasm] (R-HSA-912452)	0.462	3
UniProt:Q9H9A7 RMI1	1	RMI1 [nucleoplasm] (R-HSA-5685949)	0.462	4

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