Reactome | SUMF1 [endoplasmic reticulum lumen]

SUMF1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-1614316

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Sulfatase-modifying factor 1, SUMF1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8NBK3 SUMF1

Gene Names

SUMF1, PSEC0152, UNQ3037/PRO9852

Chain

signal peptide:1-33, chain:34-374

Reference Genes

BioGPS Gene:285362 SUMF1

COSMIC (genes):SUMF1 SUMF1

CTD Gene:285362 SUMF1

dbSNP Gene:285362 SUMF1

ENSEMBL:ENSG00000144455 SUMF1

HGNC:20376 SUMF1

KEGG Gene (Homo sapiens):285362 SUMF1

Monarch:285362 SUMF1

NCBI Gene:285362 SUMF1

OMIM:607939 SUMF1

UCSC:Q8NBK3 SUMF1

Reference Transcript

Other Identifiers

0002450239

100130207

11720731_a_at

11720732_a_at

11747815_a_at

16950269

226850_at

2660884

2660885

2660886

2660887

2660888

2660889

2660891

2660892

2660894

2660895

2660896

2660898

2660899

2660902

2660903

2660904

2660905

285362

52973_at

8085094

GE555731

GO:0003674

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0006464

GO:0006629

GO:0006687

GO:0008150

GO:0016491

GO:0018158

GO:0042802

GO:0043167

GO:0043226

GO:0043687

GO:0046872

GO:0120147

GO:1903135

HMNXSV003036233

HMNXSV003052584

Hs.302267.1.S1_3p_at

ILMN_1753472

PH_hs_0029816

Participates

as a component of

SUMF1:SUMF2 [endoplasmic reticulum lumen] (Homo sapiens)

as an input of

SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Homo sapiens)

Inferred To

Dmel\CG7049 [endoplasmic reticulum lumen] (Drosophila melanogaster)

SUMF1 [endoplasmic reticulum lumen] (Bos taurus)

SUMF1 [endoplasmic reticulum lumen] (Canis familiaris)

SUMF1 [endoplasmic reticulum lumen] (Gallus gallus)

SUMF1 [endoplasmic reticulum lumen] (Sus scrofa)

sumf1 [endoplasmic reticulum lumen] (Danio rerio)

Sumf1 [endoplasmic reticulum lumen] (Mus musculus)

Sumf1 [endoplasmic reticulum lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_001158146.1, NP_001158147.1, NP_877437.2

OpenTargets

ENSG00000144455

GeneCards

Q8NBK3

HPA

ENSG00000144455-SUMF1

Ensembl

ENSP00000384977, ENST00000405420, ENST00000383843, ENSP00000272902, ENSP00000373355, ENST00000272902, ENSG00000144455

PRO

Q8NBK3

Pharos - Targets

Q8NBK3

GlyGen

Q8NBK3

Orphanet

15570

PDB

1Y1I, 2AFY, 2AIK, 1Y1J, 1Y1E, 2HIB, 1Z70, 2AFT, 1Y1F, 2AII, 1Y1H, 1Y1G, 2HI8, 2AIJ

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.637	9
UniProt:Q8NBK3 SUMF1	1	SUMF1 [endoplasmic reticulum lumen] (R-HSA-1614316)	0.524	3
UniProt:P51688 SGSH	5	SGSH R245H [lysosomal lumen] (R-HSA-2214347) SGSH C1091del [lysosomal lumen] (R-HSA-2214344) SGSH S66W [lysosomal lumen] (R-HSA-2214340) SGSH R74C [lysosomal lumen] (R-HSA-2214341) SGSH [lysosomal lumen] (R-HSA-1678689)	0.499	2

Cite Us!