SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases

Stable Identifier
R-HSA-1614336
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Sulfatase-modifying factor 2 (SUMF2, also called C-alpha-formylglycine-generating enzyme 2, pFGE) is the paralogue of SUMF1. While SUMF1 can modify a critical residue on arylsulfatases to confer activity to them, SUMF2 lacks this ability (Mariappan et al. 2005) and instead, SUMF2 can inhibit the action of SUMF1 by dimerising with it (Zito et al. 2005). SUMF2 can interact with sulfatases with and without SUMF1 (Zito et al. 2005).

Literature References
PubMed ID Title Journal Year
15962010 Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2

Zito, E, Fraldi, A, Pepe, S, Annunziata, I, Kobinger, G, Di Natale, P, Ballabio, A, Cosma, MP

EMBO Rep 2005
15708861 Expression, localization, structural, and functional characterization of pFGE, the paralog of the Calpha-formylglycine-generating enzyme

Mariappan, M, Preusser-Kunze, A, Balleininger, M, Eiselt, N, Schmidt, B, Gande, SL, Wenzel, D, Dierks, T, von Figura, K

J Biol Chem 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created