SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases

Stable Identifier
Reaction [binding]
Homo sapiens
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Sulfatase-modifying factor 2 (SUMF2, also called C-alpha-formylglycine-generating enzyme 2, pFGE) is the paralogue of SUMF1. While SUMF1 can modify a critical residue on arylsulfatases to confer activity to them, SUMF2 lacks this ability (Mariappan et al. 2005) and instead, SUMF2 can inhibit the action of SUMF1 by dimerising with it (Zito et al. 2005). SUMF2 can interact with sulfatases with and without SUMF1 (Zito et al. 2005).

Literature References
PubMed ID Title Journal Year
15962010 Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2

Zito, E, Fraldi, A, Pepe, S, Annunziata, I, Kobinger, G, Di Natale, P, Ballabio, A, Cosma, MP

EMBO Rep 2005
15708861 Expression, localization, structural, and functional characterization of pFGE, the paralog of the Calpha-formylglycine-generating enzyme

Mariappan, M, Preusser-Kunze, A, Balleininger, M, Eiselt, N, Schmidt, B, Gande, SL, Wenzel, D, Dierks, T, von Figura, K

J Biol Chem 2005
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