Sulfatase-modifying factor 2 (SUMF2, also called C-alpha-formylglycine-generating enzyme 2, pFGE) is the paralogue of SUMF1. While SUMF1 can modify a critical residue on arylsulfatases to confer activity to them, SUMF2 lacks this ability (Mariappan et al. 2005) and instead, SUMF2 can inhibit the action of SUMF1 by dimerising with it (Zito et al. 2005). SUMF2 can interact with sulfatases with and without SUMF1 (Zito et al. 2005).
Balleininger, M, Eiselt, N, Preusser-Kunze, A, Mariappan, M, Gande, SL, von Figura, K, Wenzel, D, Dierks, T, Schmidt, B
Fraldi, A, Pepe, S, Kobinger, G, Ballabio, A, Annunziata, I, Cosma, MP, Di Natale, P, Zito, E
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