Reactome | FUCA1 [lysosomal lumen]

FUCA1 [lysosomal lumen]

Stable Identifier

R-HSA-5693804

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Tissue alpha-L-fucosidase ecNumber3.2.1.51/ecNumber, FUCO_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        FUCA1 hydrolyses NGP:1,6-GlcNAc (Homo sapiens)
        
        FUCA1 tetramer [lysosomal lumen] (Homo sapiens)
        
        FUCA1 [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04066 FUCA1

Gene Names

FUCA1, Nbla10230

Chain

signal peptide:1-31, chain:32-466

Reference Genes

BioGPS Gene:2517 FUCA1

COSMIC (genes):FUCA1 FUCA1

CTD Gene:2517 FUCA1

dbSNP Gene:2517 FUCA1

ENSEMBL:ENSG00000179163 FUCA1

HGNC:4006 FUCA1

KEGG:hsa:2517 FUCA1

Monarch:2517 FUCA1

NCBI Gene:2517 FUCA1

OMIM:612280 FUCA1

UCSC:P04066 FUCA1

Reference Transcript

RefSeq:NM_000147.4 FUCA1

Other Identifiers

11723641_a_at

11755695_a_at

11757005_a_at

16683445

202838_PM_at

202838_at

2401644

2401645

2401646

2401647

2401648

2401649

2401650

2401652

2401655

2401656

2401658

2401659

2401660

2401661

2401662

2401663

2517

4044361

41814_at

7913694

A_23_P11543

GE57910

GO:0003824

GO:0004560

GO:0005515

GO:0005576

GO:0005737

GO:0005764

GO:0005773

GO:0005975

GO:0006004

GO:0006027

GO:0006629

GO:0015928

GO:0016139

GO:0016787

GO:0016798

GO:0019377

GO:0035578

GO:0043202

GO:0043226

GO:0043231

GO:0070062

GO:1901135

HMNXSV003049787

ILMN_1752728

M29877_at

PH_hs_0000067

TC01002352.hg

g4503802_3p_at

Participates

as a component of

FUCA1 tetramer [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

FUCA1 [extracellular region]

FUCA1 [azurophil granule lumen]

Inferred To

alfA [lysosomal lumen] (Dictyostelium discoideum)

Homologues of FUCA1 [lysosomal lumen] (Dictyostelium discoideum)

Fuca [lysosomal lumen] (Drosophila melanogaster)

fuca1 [lysosomal lumen] (Xenopus tropicalis)

FUCA1 [lysosomal lumen] (Bos taurus)

FUCA1 [lysosomal lumen] (Caenorhabditis elegans)

FUCA1 [lysosomal lumen] (Canis familiaris)

FUCA1 [lysosomal lumen] (Dictyostelium discoideum)

FUCA1 [lysosomal lumen] (Gallus gallus)

FUCA1 [lysosomal lumen] (Sus scrofa)

Fuca1 [lysosomal lumen] (Mus musculus)

Fuca1 [lysosomal lumen] (Rattus norvegicus)

fuca1.2 [lysosomal lumen] (Danio rerio)

Cross References

ENSEMBL

ENSP00000363603, ENST00000374479, ENSG00000179163

OpenTargets

ENSG00000179163

ZINC - Substances

FUCO_HUMAN

ZINC - Biogenic

FUCO_HUMAN

ZINC target

P04066

PRO

P04066

GlyGen

P04066

PDB

7PLS, 7PM4

ZINC - Metabolites

FUCO_HUMAN

GeneCards

FUCA1

HPA

ENSG00000179163-FUCA1

Pharos - Targets

P04066

Orphanet

FUCA1

ZINC - Predictions - Purchasable

FUCO_HUMAN

HMDB Protein

HMDBP00875

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.556	3
UniProt:Q8NBK3 SUMF1	1	SUMF1 [endoplasmic reticulum lumen] (R-HSA-1614316)	0.527	2
UniProt:Q14554 PDIA5	1	PDIA5 [endoplasmic reticulum membrane] (R-HSA-535514)	0.527	2