Reactome | Regulation of TP53 Degradation

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Regulation of TP53 Degradation Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099707
displayName	Regulation of TP53 Degradation
eventOf	[Pathway:R-MMU-6806003] Regulation of TP53 Expression and Degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-6795667] MDM2 translocates to the cytosol - Mus musculus [Reaction:R-MMU-198599] AKT phosphorylates MDM2 - Mus musculus [Reaction:R-MMU-6795290] mTORC2 phosphorylates SGK1 - Mus musculus [Reaction:R-MMU-6795473] PDPK1 phosphorylates SGK1 - Mus musculus [Reaction:R-MMU-6795460] SGK1 phosphorylates MDM2 - Mus musculus [Reaction:R-MMU-6793666] MDM2 translocates to the nucleus - Mus musculus [Reaction:R-MMU-6804741] MDM2 forms homo- or heterodimers - Mus musculus [Reaction:R-MMU-5633460] MDM2 binds TP53 - Mus musculus [Reaction:R-MMU-6804879] MDM2 ubiquitinates TP53 - Mus musculus [Reaction:R-MMU-6793685] Ubiquitinated TP53 translocates to the cytosol - Mus musculus [Reaction:R-MMU-6804942] MDM2 homodimers auto-ubiquitinate - Mus musculus [Reaction:R-MMU-6804955] ATM phosphorylates MDM2 - Mus musculus [Reaction:R-MMU-349455] Phosphorylation of MDM4 by ATM - Mus musculus [Reaction:R-MMU-349426] Phosphorylation of MDM4 by CHEK2 - Mus musculus [Reaction:R-MMU-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Mus musculus [Reaction:R-MMU-3222072] DAXX binds Ub-MDM2 and USP7 - Mus musculus [Reaction:R-MMU-3215295] USP7 deubiquitinates MDM2 - Mus musculus [Reaction:R-MMU-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Mus musculus [Reaction:R-MMU-6805022] USP2 binds the heterodimer of MDM2 and MDM4 - Mus musculus [Reaction:R-MMU-5689972] USP2 deubiquitinates MDM2,MDM4 - Mus musculus [Reaction:R-MMU-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Mus musculus [Reaction:R-MMU-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 - Mus musculus [Reaction:R-MMU-6792863] PP2A-PP2R5C dephosphorylates MDM2 - Mus musculus [Reaction:R-MMU-6804441] RNF34 or RFFL ubiquitinates phosphorylated TP53 - Mus musculus
inferredFrom	[Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of TP53 Degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-6804757
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6806003] Regulation of TP53 Expression and Degradation
(inferredTo)	[Pathway:R-HSA-6804757] Regulation of TP53 Degradation

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