Reactome | MDM2 translocates to the nucleus

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MDM2 translocates to the nucleus Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10066899
displayName	MDM2 translocates to the nucleus
eventOf	[Pathway:R-MMU-6804757] Regulation of TP53 Degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6804955] ATM phosphorylates MDM2 - Mus musculus [Reaction:R-MMU-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 - Mus musculus [Reaction:R-MMU-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Mus musculus [Reaction:R-MMU-6804741] MDM2 forms homo- or heterodimers - Mus musculus
inferredFrom	[Reaction:R-HSA-6793666] MDM2 translocates to the nucleus - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-198638] phospho-p-S166,S188-MDM2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MDM2 translocates to the nucleus
output	[EntityWithAccessionedSequence:R-MMU-6793669] phospho-p-S166,S188-MDM2 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-198599] AKT phosphorylates MDM2 - Mus musculus [Reaction:R-MMU-6795460] SGK1 phosphorylates MDM2 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6793666
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-MMU-6804955] ATM phosphorylates MDM2 [Reaction:R-MMU-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 [Reaction:R-MMU-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 [Reaction:R-MMU-6804741] MDM2 forms homo- or heterodimers
(inferredTo)	[Reaction:R-HSA-6793666] MDM2 translocates to the nucleus