Reactome | Regulation of TP53 Expression and Degradation

Schema > Pathway > Entries

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099709
displayName	Regulation of TP53 Expression and Degradation
eventOf	[Pathway:R-MMU-5633007] Regulation of TP53 Activity - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:3132571] regulation of signal transduction by p53 class mediator
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-MMU-6804754] Regulation of TP53 Expression - Mus musculus [Pathway:R-MMU-6804757] Regulation of TP53 Degradation - Mus musculus
inferredFrom	[Pathway:R-HSA-6806003] Regulation of TP53 Expression and Degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Regulation of TP53 Expression and Degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-6806003
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEncapsulatedEvent)	[Pathway:R-MMU-201556] Signaling by ALK [Pathway:R-MMU-1257604] PIP3 activates AKT signaling [Pathway:R-MMU-6804756] Regulation of TP53 Activity through Phosphorylation
(hasEvent)	[Pathway:R-MMU-5633007] Regulation of TP53 Activity
(inferredTo)	[Pathway:R-HSA-6806003] Regulation of TP53 Expression and Degradation

Cite Us!