Reactome | SGK1 phosphorylates MDM2

Schema > Reaction > Entries

SGK1 phosphorylates MDM2 Show undefined attributes

catalystActivity	[CatalystActivity:9948042] protein serine/threonine kinase activity of p-T256,S422-SGK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9948044
displayName	SGK1 phosphorylates MDM2
eventOf	[Pathway:R-MMU-6804757] Regulation of TP53 Degradation - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6793666] MDM2 translocates to the nucleus - Mus musculus
inferredFrom	[Reaction:R-HSA-6795460] SGK1 phosphorylates MDM2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-MMU-198644] Mdm2 [cytosol]
isInDisease	false
isInferred	true
name	SGK1 phosphorylates MDM2
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-MMU-198638] phospho-Mdm2 [cytosol]
precedingEvent	[Reaction:R-MMU-6795473] PDPK1 phosphorylates SGK1 - Mus musculus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6795460
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-MMU-6793666] MDM2 translocates to the nucleus
(inferredTo)	[Reaction:R-HSA-6795460] SGK1 phosphorylates MDM2