Reactome | MDM2 translocates to the cytosol

Schema > Reaction > Entries

category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10066993
displayName	MDM2 translocates to the cytosol
eventOf	[Pathway:R-MMU-6804757] Regulation of TP53 Degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-198599] AKT phosphorylates MDM2 - Mus musculus
inferredFrom	[Reaction:R-HSA-6795667] MDM2 translocates to the cytosol - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-69486] MDM2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MDM2 translocates to the cytosol
output	[EntityWithAccessionedSequence:R-MMU-198644] MDM2 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6795667
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-MMU-198599] AKT phosphorylates MDM2
(inferredTo)	[Reaction:R-HSA-6795667] MDM2 translocates to the cytosol

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