Reactome | MDM2 forms homo- or heterodimers

Schema > Reaction > Entries

MDM2 forms homo- or heterodimers Show undefined attributes

category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10071020
displayName	MDM2 forms homo- or heterodimers
eventOf	[Pathway:R-MMU-69541] Stabilization of p53 - Mus musculus [Pathway:R-MMU-6804757] Regulation of TP53 Degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6804253] MDM2 ubiquitinates JMY - Mus musculus [Reaction:R-MMU-6798373] MDM2 ubiquitinates DYRK2 - Mus musculus [Reaction:R-MMU-349455] Phosphorylation of MDM4 by ATM - Mus musculus [Reaction:R-MMU-6804942] MDM2 homodimers auto-ubiquitinate - Mus musculus [Reaction:R-MMU-5633460] MDM2 binds TP53 - Mus musculus [Reaction:R-MMU-8952371] MDM2 binds RUNX3 - Mus musculus
inferredFrom	[Reaction:R-HSA-6804741] MDM2 forms homo- or heterodimers - Homo sapiens
input	[DefinedSet:R-MMU-6804750] p-S166,S188-MDM2,MDM4 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-MMU-6793669] phospho-p-S166,S188-MDM2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MDM2 forms homo- or heterodimers
output	[DefinedSet:R-MMU-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-6793666] MDM2 translocates to the nucleus - Mus musculus
regulatedBy	[NegativeRegulation:10071021] Negative regulation by 'p-S1981,Ac-K3016-ATM [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6804741
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-8952371] MDM2 binds RUNX3 [Reaction:R-MMU-6804253] MDM2 ubiquitinates JMY [Reaction:R-MMU-6798373] MDM2 ubiquitinates DYRK2 [Reaction:R-MMU-349455] Phosphorylation of MDM4 by ATM [Reaction:R-MMU-6804942] MDM2 homodimers auto-ubiquitinate [Reaction:R-MMU-5633460] MDM2 binds TP53
(hasEvent)	[Pathway:R-MMU-69541] Stabilization of p53 [Pathway:R-MMU-6804757] Regulation of TP53 Degradation
(inferredTo)	[Reaction:R-HSA-6804741] MDM2 forms homo- or heterodimers