Reactome | MDM2 homodimers auto-ubiquitinate

Schema > Reaction > Entries

MDM2 homodimers auto-ubiquitinate Show undefined attributes

catalystActivity	[CatalystActivity:10071027] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10071029
displayName	MDM2 homodimers auto-ubiquitinate
eventOf	[Pathway:R-MMU-6804757] Regulation of TP53 Degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-3222072] DAXX binds Ub-MDM2 and USP7 - Mus musculus
inferredFrom	[Reaction:R-HSA-6804942] MDM2 homodimers auto-ubiquitinate - Homo sapiens
input	[Complex:R-MMU-6804933] p-S166,S188-MDM2 dimer [nucleoplasm] 2 × [DefinedSet:R-MMU-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MDM2 homodimers auto-ubiquitinate
output	[Complex:R-MMU-6804935] PolyUb,p-S166,S188-MDM2 homodimer [nucleoplasm]
precedingEvent	[Reaction:R-MMU-6804741] MDM2 forms homo- or heterodimers - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6804942
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-MMU-3222072] DAXX binds Ub-MDM2 and USP7
(inferredTo)	[Reaction:R-HSA-6804942] MDM2 homodimers auto-ubiquitinate

Cite Us!