Reactome | Phosphorylation of MDM4 by CHEK2

Schema > Reaction > Entries

Phosphorylation of MDM4 by CHEK2 Show undefined attributes

catalystActivity	[CatalystActivity:9985859] protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10007847
displayName	Phosphorylation of MDM4 by CHEK2
eventOf	[Pathway:R-MMU-69541] Stabilization of p53 - Mus musculus [Pathway:R-MMU-6804757] Regulation of TP53 Degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6804724] MDM2 ubiquitinates phosphorylated MDM4 - Mus musculus
inferredFrom	[Reaction:R-HSA-349426] Phosphorylation of MDM4 by CHEK2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-MMU-6804939] p-S166,S188-MDM2:p-S403-MDM4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of MDM4 by CHEK2
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-MMU-6804936] p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-349455] Phosphorylation of MDM4 by ATM - Mus musculus [Reaction:R-MMU-5683792] p-T68-CHEK2 autophosphorylates - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-349426
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-69541] Stabilization of p53 [Pathway:R-MMU-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-MMU-6804724] MDM2 ubiquitinates phosphorylated MDM4
(inferredTo)	[Reaction:R-HSA-349426] Phosphorylation of MDM4 by CHEK2