Reactome | USP2 deubiquitinates MDM2,MDM4

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USP2 deubiquitinates MDM2,MDM4 Show undefined attributes

catalystActivity	[CatalystActivity:10062272] cysteine-type deubiquitinase activity of USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10062274
displayName	USP2 deubiquitinates MDM2,MDM4
eventOf	[Pathway:R-MMU-5689880] Ub-specific processing proteases - Mus musculus [Pathway:R-MMU-6804757] Regulation of TP53 Degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5689972] USP2 deubiquitinates MDM2,MDM4 - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-MMU-6782767] USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	USP2 deubiquitinates MDM2,MDM4
output	[Complex:R-MMU-6804936] p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] [DefinedSet:R-MMU-6782682] PolyUb [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5689946] USP2 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-6805022] USP2 binds the heterodimer of MDM2 and MDM4 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5689972
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5689880] Ub-specific processing proteases [Pathway:R-MMU-6804757] Regulation of TP53 Degradation
(inferredTo)	[Reaction:R-HSA-5689972] USP2 deubiquitinates MDM2,MDM4