Reactome | (CDK1,CDK2):CCNA phosphorylates MDM2 at T218

Schema > Reaction > Entries

(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 Show undefined attributes

catalystActivity	[CatalystActivity:10066895] cyclin-dependent protein serine/threonine kinase activity of CCNA:p-CDK1/2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10066897
displayName	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218
eventOf	[Pathway:R-MMU-6804757] Regulation of TP53 Degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 - Mus musculus
inferredFrom	[Reaction:R-HSA-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-6793669] phospho-p-S166,S188-MDM2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-6792862] phospho-p-S166,S188,T218-MDM2 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-6793666] MDM2 translocates to the nucleus - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6793661
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-MMU-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2
(inferredTo)	[Reaction:R-HSA-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218

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