Reactome | Estrogen-dependent nuclear events downstream of ESR-membrane signaling

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Estrogen-dependent nuclear events downstream of ESR-membrane signaling Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
created	[InstanceEdit:9634637] Rothfels, Karen, 2019-01-12
dbId	9634638
displayName	Estrogen-dependent nuclear events downstream of ESR-membrane signaling
eventOf	[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-199298] AKT phosphorylates CREB1 - Homo sapiens [Reaction:R-HSA-111916] Dimerization of p-S133-CREB1 - Homo sapiens [Reaction:R-HSA-9623341] p-S133 CREB1 dimer binds the CCND1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9623355] ESR1-dependent CCND1 expression - Homo sapiens [BlackBoxEvent:R-HSA-9625465] E2-mediated FOS gene expression - Homo sapiens [Reaction:R-HSA-9632868] CDKN1B is phosphorylated in response to estrogen - Homo sapiens [BlackBoxEvent:R-HSA-9632873] p-S10 CDKN1B translocates to the cytosol - Homo sapiens [BlackBoxEvent:R-HSA-9623999] BCL gene expression downstream of ESR1 - Homo sapiens [Reaction:R-HSA-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR - Homo sapiens [BlackBoxEvent:R-HSA-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Homo sapiens [Reaction:R-HSA-198731] ERK1/2 activates ELK1 - Homo sapiens [Reaction:R-HSA-9625479] SRF and ELK1 bind the FOS gene - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:9027656] Integration of the extranuclear and nuclear actions of estrogen [LiteratureReference:9632158] Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer [LiteratureReference:9632146] Cracking the estrogen receptor's posttranslational code in breast tumors
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Estrogen-dependent nuclear events downstream of ESR-membrane signaling
orthologousEvent	[Pathway:R-CEL-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Caenorhabditis elegans [Pathway:R-DME-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Drosophila melanogaster [Pathway:R-GGA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Gallus gallus [Pathway:R-XTR-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Xenopus tropicalis [Pathway:R-DRE-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Danio rerio [Pathway:R-SSC-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Sus scrofa [Pathway:R-BTA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Bos taurus [Pathway:R-CFA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Canis familiaris [Pathway:R-RNO-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Rattus norvegicus [Pathway:R-MMU-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Mus musculus
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9634638
summation	[Summation:9634655] Although membrane-localized estrogen receptors stimulate rap...
updateTrackers	[UpdateTracker:9846621] Update Tracker - [Pathway:9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - v84:[updateContainedRLE] [UpdateTracker:9864274] Update Tracker - [Pathway:9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - v88:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9846621] Update Tracker - [Pathway:9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - v84:[updateContainedRLE] [UpdateTracker:9864274] Update Tracker - [Pathway:9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - v88:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling

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