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Schema
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Reaction
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Entries
CDKN1B is phosphorylated in response to estrogen
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authored
[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
catalystActivity
[CatalystActivity:9632837] protein serine/threonine kinase activity of UHMK1 [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9632867] Rothfels, Karen, 2018-12-21
dbId
9632868
displayName
CDKN1B is phosphorylated in response to estrogen
eventOf
[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9632873] p-S10 CDKN1B translocates to the cytosol - Homo sapiens
input
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-182563] CDKN1B [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9632803] The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer
[LiteratureReference:9632812] p27(Kip1) signaling: Transcriptional and post-translational regulation
[LiteratureReference:8949850] Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability
[LiteratureReference:9632817] p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
[LiteratureReference:9632793] Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export
[LiteratureReference:9632796] Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1
[LiteratureReference:8949545] Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
[LiteratureReference:9632778] Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway
[LiteratureReference:9632798] Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells
[LiteratureReference:9632786] Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway
[LiteratureReference:9632805] Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells
[LiteratureReference:9634609] A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression
modified
[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name
CDKN1B is phosphorylated in response to estrogen
orthologousEvent
[Reaction:R-GGA-9632868] CDKN1B is phosphorylated in response to estrogen - Gallus gallus
[Reaction:R-DRE-9632868] CDKN1B is phosphorylated in response to estrogen - Danio rerio
[Reaction:R-SSC-9632868] CDKN1B is phosphorylated in response to estrogen - Sus scrofa
[Reaction:R-BTA-9632868] CDKN1B is phosphorylated in response to estrogen - Bos taurus
[Reaction:R-CFA-9632868] CDKN1B is phosphorylated in response to estrogen - Canis familiaris
[Reaction:R-RNO-9632868] CDKN1B is phosphorylated in response to estrogen - Rattus norvegicus
[Reaction:R-MMU-9632868] CDKN1B is phosphorylated in response to estrogen - Mus musculus
output
[SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9632832] p-S10 CDKN1B [nucleoplasm]
releaseDate
2019-03-20
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9632868
summation
[Summation:9632851] CDKN1B (also known as p27 KIP) is an inhibitor of G1 cyclin ...
Referrals
(hasEvent)
[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling
(precedingEvent)
[BlackBoxEvent:R-HSA-9632873] p-S10 CDKN1B translocates to the cytosol
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