Reactome | BCL gene expression downstream of ESR1

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BCL gene expression downstream of ESR1 Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9624001] Rothfels, Karen, 2018-10-05
dbId	9623999
displayName	BCL gene expression downstream of ESR1
eventOf	[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8948460] BCL2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9637881] Estrogen alters thresholds for B cell apoptosis and activation [LiteratureReference:9637885] Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation [LiteratureReference:9637896] Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells [LiteratureReference:9637905] The emerging role of estrogen in B cell malignancies
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BCL gene expression downstream of ESR1
output	[EntityWithAccessionedSequence:R-HSA-50757] BCL2 [mitochondrial outer membrane]
regulatedBy	[PositiveGeneExpressionRegulation:9624002] Positive gene expression regulation by 'p-S133-CREB1 homodimer [nucleoplasm]'
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9623999
summation	[Summation:9624000] BCL2 mRNA and protein levels increase in response to E2 stim...

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[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling

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