Reactome | p-S133 CREB1 dimer binds the CCND1 promoter

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p-S133 CREB1 dimer binds the CCND1 promoter Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9623339] Rothfels, Karen, 2018-10-03
dbId	9623341
displayName	p-S133 CREB1 dimer binds the CCND1 promoter
eventOf	[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9623355] ESR1-dependent CCND1 expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8853953] CCND1 gene [nucleoplasm] [Complex:R-HSA-111911] p-S133-CREB1 homodimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9623209] 17beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression [LiteratureReference:9623301] 17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression [LiteratureReference:9623938] 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30 [LiteratureReference:9623987] The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells [LiteratureReference:9623957] G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells [LiteratureReference:9623943] Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells [LiteratureReference:9623972] Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation [LiteratureReference:9623979] The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells [LiteratureReference:9622913] A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis [LiteratureReference:9632772] Cell proliferation regulated by estradiol receptor: Therapeutic implications [LiteratureReference:9632114] PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells [LiteratureReference:9632798] Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells [LiteratureReference:9632116] Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells [LiteratureReference:9632788] Non-transcriptional action of oestradiol and progestin triggers DNA synthesis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-S133 CREB1 dimer binds the CCND1 promoter
output	[Complex:R-HSA-9623342] CCND1 gene:p-S133 CREB1 dimer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-111916] Dimerization of p-S133-CREB1 - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9623341
summation	[Summation:9623340] Estrogen stimulation promotes cell cycle progression in a nu...

Referrals

(hasEvent)	[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-9623355] ESR1-dependent CCND1 expression

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