Reactome | ESR1-dependent CCND1 expression

Schema > BlackBoxEvent > Entries

ESR1-dependent CCND1 expression Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9623354] Rothfels, Karen, 2018-10-03
dbId	9623355
displayName	ESR1-dependent CCND1 expression
eventOf	[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8853953] CCND1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9637967] Reduction in cyclin D1/Cdk4/retinoblastoma protein signaling by CRE-decoy oligonucleotide [LiteratureReference:9637961] Estrogen-induced G1/S transition of G0-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ESR1-dependent CCND1 expression
output	[EntityWithAccessionedSequence:R-HSA-68328] CCND1 [cytosol]
precedingEvent	[Reaction:R-HSA-9623341] p-S133 CREB1 dimer binds the CCND1 promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9623347] Positive gene expression regulation by 'CCND1 gene:p-S133 CREB1 dimer [nucleoplasm]'
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9623355
summation	[Summation:9623353] Expression of CCND1, the gene encoding cyclin D1, is stimula...

Referrals

(hasEvent)	[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling
(precedingEvent)	[Reaction:R-HSA-8941895] Formation of CDK4/6:CCND complexes

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