Reactome | p-S10 CDKN1B translocates to the cytosol

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p-S10 CDKN1B translocates to the cytosol Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:459] cytoplasm
created	[InstanceEdit:9632872] Rothfels, Karen, 2018-12-21
dbId	9632873
displayName	p-S10 CDKN1B translocates to the cytosol
eventOf	[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9632832] p-S10 CDKN1B [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9632817] p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis [LiteratureReference:9632798] Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells [LiteratureReference:8949865] The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	p-S10 CDKN1B translocates to the cytosol
orthologousEvent	[BlackBoxEvent:R-CEL-9632873] p-S10 CDKN1B translocates to the cytosol - Caenorhabditis elegans [BlackBoxEvent:R-DME-9632873] p-S10 CDKN1B translocates to the cytosol - Drosophila melanogaster [BlackBoxEvent:R-GGA-9632873] p-S10 CDKN1B translocates to the cytosol - Gallus gallus [BlackBoxEvent:R-XTR-9632873] p-S10 CDKN1B translocates to the cytosol - Xenopus tropicalis [BlackBoxEvent:R-DRE-9632873] p-S10 CDKN1B translocates to the cytosol - Danio rerio [BlackBoxEvent:R-SSC-9632873] p-S10 CDKN1B translocates to the cytosol - Sus scrofa [BlackBoxEvent:R-BTA-9632873] p-S10 CDKN1B translocates to the cytosol - Bos taurus [BlackBoxEvent:R-CFA-9632873] p-S10 CDKN1B translocates to the cytosol - Canis familiaris [BlackBoxEvent:R-RNO-9632873] p-S10 CDKN1B translocates to the cytosol - Rattus norvegicus [BlackBoxEvent:R-MMU-9632873] p-S10 CDKN1B translocates to the cytosol - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-9632829] p-S10 CDKN1B [cytosol]
precedingEvent	[Reaction:R-HSA-9632868] CDKN1B is phosphorylated in response to estrogen - Homo sapiens
regulatedBy	[PositiveRegulation:9632874] Positive regulation by 'XPO1 [nucleoplasm]' [PositiveRegulation:9632861] Positive regulation by 'p-Y185,Y187 MAPK1 dimer [nucleoplasm]'
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9632873
summation	[Summation:9632901] Estrogen stimulation causes a partial redistribution of CDK...

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(hasEvent)

[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling