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Schema
>
Reaction
>
Entries
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
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authored
[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
catalystActivity
[CatalystActivity:199274] protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9624529] Rothfels, Karen, 2018-10-11
dbId
9624526
displayName
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
eventOf
[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Homo sapiens
input
3 ×
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-199305] FOXO3 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9637889] Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins
[LiteratureReference:9027656] Integration of the extranuclear and nuclear actions of estrogen
[LiteratureReference:199277] Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
[LiteratureReference:9624501] A brief introduction to FOXOlogy
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
orthologousEvent
[Reaction:R-DME-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR - Drosophila melanogaster
[Reaction:R-CEL-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR - Caenorhabditis elegans
[Reaction:R-GGA-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR - Gallus gallus
[Reaction:R-DRE-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR - Danio rerio
[Reaction:R-RNO-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR - Rattus norvegicus
[Reaction:R-MMU-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR - Mus musculus
output
3 ×
[SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-199289] p-T32,S253,S315-FOXO3 [nucleoplasm]
releaseDate
2019-03-20
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9624526
summation
[Summation:9624530] AKT phosphorylation of the pro-apoptotic Forkhead transcript...
Referrals
(hasEvent)
[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling
(precedingEvent)
[BlackBoxEvent:R-HSA-9624527] AKT-phosphorylated FOXO3 translocates to cytosol
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