Reactome | AKT-phosphorylated FOXO3 translocates to cytosol

Schema > BlackBoxEvent > Entries

AKT-phosphorylated FOXO3 translocates to cytosol Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9624529] Rothfels, Karen, 2018-10-11
dbId	9624527
displayName	AKT-phosphorylated FOXO3 translocates to cytosol
eventOf	[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-199289] p-T32,S253,S315-FOXO3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9637889] Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins [LiteratureReference:199277] Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor [LiteratureReference:9027656] Integration of the extranuclear and nuclear actions of estrogen [LiteratureReference:9624501] A brief introduction to FOXOlogy
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	AKT-phosphorylated FOXO3 translocates to cytosol
orthologousEvent	[BlackBoxEvent:R-DME-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Drosophila melanogaster [BlackBoxEvent:R-CEL-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Caenorhabditis elegans [BlackBoxEvent:R-GGA-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Gallus gallus [BlackBoxEvent:R-XTR-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Xenopus tropicalis [BlackBoxEvent:R-DRE-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Danio rerio [BlackBoxEvent:R-SSC-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Sus scrofa [BlackBoxEvent:R-BTA-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Bos taurus [BlackBoxEvent:R-CFA-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Canis familiaris [BlackBoxEvent:R-RNO-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Rattus norvegicus [BlackBoxEvent:R-MMU-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-9614413] p-T32,S253,S315-FOXO3 [cytosol]
precedingEvent	[Reaction:R-HSA-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9624527
summation	[Summation:9624528] AKT-mediated phosphorylation of FOXO3 downstream of estrogen...

Referrals

(hasEvent)

[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling