Reactome | SRF and ELK1 bind the FOS gene

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SRF and ELK1 bind the FOS gene Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9625480] Rothfels, Karen, 2018-10-19
dbId	9625479
displayName	SRF and ELK1 bind the FOS gene
eventOf	[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8948462] FOS gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3009350] p-4S,T336-ELK1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5666000] SRF [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9625301] The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain [LiteratureReference:199346] ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation [LiteratureReference:9625249] Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1 [LiteratureReference:9625265] Journey to the surface of the cell: Fos regulation and the SRE [LiteratureReference:9625294] The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells [LiteratureReference:9623938] 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30 [LiteratureReference:9625244] Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor ? (ER?)
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SRF and ELK1 bind the FOS gene
output	[Complex:R-HSA-9625460] FOS gene:SRF:p-4S,T336 ELK1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-198731] ERK1/2 activates ELK1 - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9625479
summation	[Summation:9625477] SRF and phosphorylated ELK1 bind to sterol response elements...

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(hasEvent)

[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling