Reactome | Dimerization of p-IRF7

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Dimerization of p-IRF7 Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:933535] Garapati, P V, 2010-08-16
dbId	933533
displayName	Dimerization of p-IRF7
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Homo sapiens [Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation - Homo sapiens
followingEvent	[Reaction:R-HSA-9604487] p-IRF7:p-IRF7 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-933531] Translocation of p-IRF7:p-IRF7 to nucleus - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-450318] p-S477,S479-IRF7 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:933500] Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain [LiteratureReference:933439] Structural insights into interferon regulatory factor activation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Dimerization of p-IRF7
orthologousEvent	[Reaction:R-GGA-933533] Dimerization of p-IRF7 - Gallus gallus [Reaction:R-XTR-933533] Dimerization of p-IRF7 - Xenopus tropicalis [Reaction:R-DRE-933533] Dimerization of p-IRF7 - Danio rerio [Reaction:R-SSC-933533] Dimerization of p-IRF7 - Sus scrofa [Reaction:R-BTA-933533] Dimerization of p-IRF7 - Bos taurus [Reaction:R-RNO-933533] Dimerization of p-IRF7 - Rattus norvegicus [Reaction:R-MMU-933533] Dimerization of p-IRF7 - Mus musculus
output	[Complex:R-HSA-450344] p-2S-IRF7:p-2S-IRF7 [cytosol]
precedingEvent	[Reaction:R-HSA-933525] Phosphorylation and release of IRF7 - Homo sapiens [Reaction:R-HSA-975106] Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-933533
summation	[Summation:933444] Phosphorylation stimulates the C-terminal autoinhibitory dom...

Referrals

(hasEvent)	[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling [Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation
(precedingEvent)	[Reaction:R-HSA-9604487] p-IRF7:p-IRF7 translocates to the nucleus [Reaction:R-HSA-933531] Translocation of p-IRF7:p-IRF7 to nucleus