Reactome | TRAF mediated activation of IRF

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TRAF mediated activation of IRF Show undefined attributes

authored	[InstanceEdit:1168652] Shamovsky, V, 2011-01-04
created	[InstanceEdit:1227896] Shamovsky, V, 2011-03-10
dbId	1227882
displayName	TRAF mediated activation of IRF
edited	[InstanceEdit:1280191] Shamovsky, V, 2011-05-11
eventOf	[Pathway:R-GGA-1227887] RLR (RIG-like receptor) mediated induction of IFN alpha/beta - Gallus gallus
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-1227891] TRAF3/or TRAF6 interacts with IPS-1 - Gallus gallus [BlackBoxEvent:R-GGA-1227893] TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex - Gallus gallus [Reaction:R-GGA-1227867] TANK binds polyubiquitinated TRAF3/6 - Gallus gallus [Reaction:R-GGA-1227885] TBK1/IKK epsilon bind to TANK:TRAF3/TRAF6 complex followed by their activation - Gallus gallus [Reaction:R-GGA-1227863] Recruitment of IRF to activated TBK1/IKK epsilon - Gallus gallus [Reaction:R-GGA-1227881] Phosphorylation and release of IRF3 - Gallus gallus [Reaction:R-GGA-434027] Dimerization of Phospho-IRF3 - Gallus gallus [Reaction:R-GGA-433967] Dimerized Phospho-IRF3 is Transported To The Nucleus - Gallus gallus
inferredFrom	[Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway - Homo sapiens [Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation - Homo sapiens
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response [LiteratureReference:918292] TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA
maxDepth	2
modified	[InstanceEdit:9856143] Shamovsky, Veronica, 2023-12-11
name	TRAF mediated activation of IRF
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1295492] Garapati, P V, 2011-05-16
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-1227882
summation	[Summation:1237353] Once activated, IPS-1 recruits TRAFs (TNF receptor associate...

Referrals

(hasEvent)	[Pathway:R-GGA-1227887] RLR (RIG-like receptor) mediated induction of IFN alpha/beta
(inferredTo)	[Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation [Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway