Reactome | ARBB recruits GPCRs into clathrin-coated pits

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ARBB recruits GPCRs into clathrin-coated pits Show undefined attributes

authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8866272] Rothfels, Karen, 2016-03-29
dbId	8866283
displayName	ARBB recruits GPCRs into clathrin-coated pits
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
eventOf	[Pathway:R-HSA-8856825] Cargo recognition for clathrin-mediated endocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Homo sapiens
input	[Complex:R-HSA-8866263] ARRB:ARRB-binding GPCRs [plasma membrane] [Complex:R-HSA-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8866171] Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin [LiteratureReference:8864915] Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor [LiteratureReference:8866139] Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain [LiteratureReference:8866179] The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis [LiteratureReference:8851792] The structural basis of arrestin-mediated regulation of G-protein-coupled receptors [LiteratureReference:8866200] The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	ARBB recruits GPCRs into clathrin-coated pits
orthologousEvent	[Reaction:R-CEL-8866283] ARBB recruits GPCRs into clathrin-coated pits - Caenorhabditis elegans [Reaction:R-DME-8866283] ARBB recruits GPCRs into clathrin-coated pits - Drosophila melanogaster [Reaction:R-GGA-8866283] ARBB recruits GPCRs into clathrin-coated pits - Gallus gallus [Reaction:R-XTR-8866283] ARBB recruits GPCRs into clathrin-coated pits - Xenopus tropicalis [Reaction:R-SSC-8866283] ARBB recruits GPCRs into clathrin-coated pits - Sus scrofa [Reaction:R-BTA-8866283] ARBB recruits GPCRs into clathrin-coated pits - Bos taurus [Reaction:R-CFA-8866283] ARBB recruits GPCRs into clathrin-coated pits - Canis familiaris [Reaction:R-RNO-8866283] ARBB recruits GPCRs into clathrin-coated pits - Rattus norvegicus [Reaction:R-MMU-8866283] ARBB recruits GPCRs into clathrin-coated pits - Mus musculus
output	[Complex:R-HSA-8866265] ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane]
precedingEvent	[Reaction:R-HSA-8866269] ARRB bind GPCRs - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8866289] Negative regulation by 'UBQLN2:UIM-containing proteins [cytosol]'
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8866283
summation	[Summation:8866270] Interaction between beta-arrestins and components of the cla...

Referrals

(hasEvent)	[Pathway:R-HSA-8856825] Cargo recognition for clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

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