Reactome | Epsin family proteins bind ubiquitinated cargo

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Epsin family proteins bind ubiquitinated cargo Show undefined attributes

authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8866272] Rothfels, Karen, 2016-03-29
dbId	8866279
displayName	Epsin family proteins bind ubiquitinated cargo
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
eventOf	[Pathway:R-HSA-8856825] Cargo recognition for clathrin-mediated endocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Homo sapiens
input	[DefinedSet:R-HSA-8866243] EPS15,EPN1,EPN2 [cytosol] [DefinedSet:R-HSA-8866252] ubiquitinated cargo [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8866219] Ubiquitin-dependent sorting in endocytosis [LiteratureReference:8866152] Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis [LiteratureReference:183075] The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module [LiteratureReference:8866134] A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins [LiteratureReference:8866164] Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis [LiteratureReference:8866165] Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation [LiteratureReference:8863700] Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly [LiteratureReference:8866183] The epsin protein family: coordinators of endocytosis and signaling [LiteratureReference:8866197] The role of ubiquitylation in receptor endocytosis and endosomal sorting [LiteratureReference:8870585] Endocytosis and signalling: intertwining molecular networks [LiteratureReference:8870887] Regulation of clathrin-mediated endocytosis by dynamic ubiquitination and deubiquitination
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Epsin family proteins bind ubiquitinated cargo
orthologousEvent	[Reaction:R-CEL-8866279] Epsin family proteins bind ubiquitinated cargo - Caenorhabditis elegans [Reaction:R-DME-8866279] Epsin family proteins bind ubiquitinated cargo - Drosophila melanogaster [Reaction:R-GGA-8866279] Epsin family proteins bind ubiquitinated cargo - Gallus gallus [Reaction:R-XTR-8866279] Epsin family proteins bind ubiquitinated cargo - Xenopus tropicalis [Reaction:R-SSC-8866279] Epsin family proteins bind ubiquitinated cargo - Sus scrofa [Reaction:R-BTA-8866279] Epsin family proteins bind ubiquitinated cargo - Bos taurus [Reaction:R-CFA-8866279] Epsin family proteins bind ubiquitinated cargo - Canis familiaris [Reaction:R-RNO-8866279] Epsin family proteins bind ubiquitinated cargo - Rattus norvegicus [Reaction:R-MMU-8866279] Epsin family proteins bind ubiquitinated cargo - Mus musculus
output	[Complex:R-HSA-8866261] EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8866279
summation	[Summation:8866273] Some membrane cargo is sorted into clathrin-coated pits afte...

Referrals

(hasEvent)	[Pathway:R-HSA-8856825] Cargo recognition for clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

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