CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

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Reaction [binding]
Homo sapiens
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CLASP proteins are recruited to nascent clathrin-coated pits (CCPs) through interactions with AP-2 and clathrin. Although in this pathway cargo recruitment is depicted as occuring after the recruitment of bulk AP-2 and clathrin, a number of studies suggest that they are largely recruited concomitantly (Liu et al, 2010; reviewed in McMahon and Boucrot, 2011). Concurrent interactions with sorting signals in cargo cytoplasmic tails and with clathrin and/or AP-2 ensure that CLASPs and cargo are incorporated into the emerging CCP (Schmid et al, 2006; Edeling et al, 2006; reviewed in Traub, 2009; Traub and Bonifacino, 2013; Kirchausen et al, 2014). In addition, incorporation of CLASPs and cargo may play a role in regulating the timing and dynamics of endocytosis (Loerke et al, 2009; Mettlen et al, 2009; Soohoo et al, 2013; Mettlen et al, 2010; Puthenveedu et al, 2005).

Literature References
PubMed ID Title Journal Year
16516836 Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly

Steinhauser, AL, Keyel, PA, Edeling, MA, Owen, DJ, Heuser, JE, Mishra, SK, Traub, LM, Collins, BM, Roth, R

Dev. Cell 2006
19458185 Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits

Stoeber, M, Loerke, D, Antonescu, CN, Mettlen, M, Danuser, G, Schmid, SL

Mol. Biol. Cell 2009
21779028 Molecular mechanism and physiological functions of clathrin-mediated endocytosis

Boucrot, E, McMahon, HT

Nat. Rev. Mol. Cell Biol. 2011
21187331 Local clustering of transferrin receptors promotes clathrin-coated pit initiation

Liu, AP, Aguet, F, Danuser, G, Schmid, SL

J. Cell Biol. 2010
24789820 Molecular structure, function, and dynamics of clathrin-mediated membrane traffic

Owen, D, Kirchhausen, T, Harrison, SC

Cold Spring Harb Perspect Biol 2014
19296720 Cargo and dynamin regulate clathrin-coated pit maturation

Jaqaman, H, Yarar, D, Loerke, D, Jaqaman, K, Mettlen, M, Danuser, G, Schmid, SL

PLoS Biol. 2009
24186068 Cargo recognition in clathrin-mediated endocytosis

Traub, LM, Bonifacino, JS

Cold Spring Harb Perspect Biol 2013
17018281 Cargo regulates clathrin-coated pit dynamics

Puthenveedu, MA, von Zastrow, M

Cell 2006
19696796 Tickets to ride: selecting cargo for clathrin-regulated internalization

Traub, LM

Nat. Rev. Mol. Cell Biol. 2009
20231386 Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis

Yarar, D, Loerke, D, Mettlen, M, Danuser, G, Schmid, SL

J. Cell Biol. 2010
16903783 Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly

McMahon, HT, Ford, MG, Praefcke, GJ, Benmerah, A, Burtey, A, Peak-Chew, SY, Schmid, EM, Mills, IG

PLoS Biol. 2006
23536704 Divergent modes for cargo-mediated control of clathrin-coated pit dynamics

Soohoo, AL, Puthenveedu, MA

Mol. Biol. Cell 2013
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