Reactome | PICALM binds R-SNAREs

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PICALM binds R-SNAREs Show undefined attributes

authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8867612] Rothfels, Karen, 2016-04-15
dbId	8867613
displayName	PICALM binds R-SNAREs
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
eventOf	[Pathway:R-HSA-8856825] Cargo recognition for clathrin-mediated endocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Homo sapiens
input	[CandidateSet:R-HSA-8867602] PICALMs [cytosol] [DefinedSet:R-HSA-8867604] VAMP2,3,8 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8867589] The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM [LiteratureReference:8867575] Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PICALM binds R-SNAREs
orthologousEvent	[Reaction:R-DDI-8867613] PICALM binds R-SNAREs - Dictyostelium discoideum [Reaction:R-CEL-8867613] PICALM binds R-SNAREs - Caenorhabditis elegans [Reaction:R-DME-8867613] PICALM binds R-SNAREs - Drosophila melanogaster [Reaction:R-GGA-8867613] PICALM binds R-SNAREs - Gallus gallus [Reaction:R-SSC-8867613] PICALM binds R-SNAREs - Sus scrofa [Reaction:R-BTA-8867613] PICALM binds R-SNAREs - Bos taurus [Reaction:R-CFA-8867613] PICALM binds R-SNAREs - Canis familiaris [Reaction:R-RNO-8867613] PICALM binds R-SNAREs - Rattus norvegicus [Reaction:R-MMU-8867613] PICALM binds R-SNAREs - Mus musculus
output	[Complex:R-HSA-8867601] PICALM:VAMP2,3,8 [plasma membrane]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8867613
summation	[Summation:8867611] PICALM is a phosphatidylinositol-binding clathrin assembly p...

Referrals

(hasEvent)	[Pathway:R-HSA-8856825] Cargo recognition for clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit