Reactome | ARRB bind GPCRs

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ARRB bind GPCRs Show undefined attributes

authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8866272] Rothfels, Karen, 2016-03-29
dbId	8866269
displayName	ARRB bind GPCRs
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
eventOf	[Pathway:R-HSA-8856825] Cargo recognition for clathrin-mediated endocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-8866283] ARBB recruits GPCRs into clathrin-coated pits - Homo sapiens [Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Homo sapiens
input	[DefinedSet:R-HSA-1911410] ARRB [cytosol] [CandidateSet:R-HSA-8866250] ARRB-binding GPCRs [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8864925] Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization [LiteratureReference:8864915] Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor [LiteratureReference:5138423] Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4 [LiteratureReference:8864907] Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors [LiteratureReference:8864919] Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway [LiteratureReference:8864899] Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways [LiteratureReference:8864622] Cargo recognition in clathrin-mediated endocytosis [LiteratureReference:8864929] Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex [LiteratureReference:8851792] The structural basis of arrestin-mediated regulation of G-protein-coupled receptors [LiteratureReference:8864680] Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly [LiteratureReference:8863700] Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly [LiteratureReference:8866175] Role of ?-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking [LiteratureReference:8870614] ?-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	ARRB bind GPCRs
orthologousEvent	[Reaction:R-CEL-8866269] ARRB bind GPCRs - Caenorhabditis elegans [Reaction:R-DME-8866269] ARRB bind GPCRs - Drosophila melanogaster [Reaction:R-GGA-8866269] ARRB bind GPCRs - Gallus gallus [Reaction:R-XTR-8866269] ARRB bind GPCRs - Xenopus tropicalis [Reaction:R-DRE-8866269] ARRB bind GPCRs - Danio rerio [Reaction:R-SSC-8866269] ARRB bind GPCRs - Sus scrofa [Reaction:R-BTA-8866269] ARRB bind GPCRs - Bos taurus [Reaction:R-CFA-8866269] ARRB bind GPCRs - Canis familiaris [Reaction:R-RNO-8866269] ARRB bind GPCRs - Rattus norvegicus [Reaction:R-MMU-8866269] ARRB bind GPCRs - Mus musculus
output	[Complex:R-HSA-8866263] ARRB:ARRB-binding GPCRs [plasma membrane]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8866269
summation	[Summation:8866280] Beta arrestins 1 and 2 are required for the endocytosis and ...

Referrals

(hasEvent)	[Pathway:R-HSA-8856825] Cargo recognition for clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-HSA-8866283] ARBB recruits GPCRs into clathrin-coated pits [Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

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