Reactome | CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

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CLASP proteins and cargo are recruited to the nascent clathrin-coated pit Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9959642
displayName	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
eventOf	[Pathway:R-MMU-8856828] Clathrin-mediated endocytosis - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8868071] Clathrin recruits PIK3C2A - Mus musculus
inferredFrom	[Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Homo sapiens
input	[DefinedSet:R-MMU-8867603] CLASP proteins:cargo [plasma membrane] [Complex:R-MMU-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
isInDisease	false
isInferred	true
name	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
output	[Complex:R-MMU-8867753] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane]
precedingEvent	[Reaction:R-MMU-8866277] AP-2 directly binds some endocytic cargo - Mus musculus [Reaction:R-MMU-8866283] ARBB recruits GPCRs into clathrin-coated pits - Mus musculus [Reaction:R-MMU-8866269] ARRB bind GPCRs - Mus musculus [Reaction:R-MMU-8863472] DAB2 binds LRP2 - Mus musculus [Reaction:R-MMU-8866279] Epsin family proteins bind ubiquitinated cargo - Mus musculus [Reaction:R-MMU-8863471] LDLR is bound by DAB2 and ARH - Mus musculus [Reaction:R-MMU-8867613] PICALM binds R-SNAREs - Mus musculus [Reaction:R-MMU-8863463] STON2 binds SYT proteins - Mus musculus [Reaction:R-MMU-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Mus musculus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8867756
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8856828] Clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-MMU-8868071] Clathrin recruits PIK3C2A
(inferredTo)	[Reaction:R-HSA-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit