Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes

authored
catalystActivity
catalystActivityReference [CatalystActivityReference:9643320] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
category transition
compartment
dbId 69227
displayName Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
edited
eventOf
figure
followingEvent
input
isInDisease false
isInferred false
literatureReference
modified [InstanceEdit:10660109] Weiser, JD, 2021-09-10
name
  • Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
orthologousEvent
output
precedingEvent
releaseDate 2004-07-06
reviewed
revised
schemaClass Reaction
species
stId R-HSA-69227
summation
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