Reactome | E2F1 binds the CDC25A gene promoter

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E2F1 binds the CDC25A gene promoter Show undefined attributes

authored	[InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8961962] Orlic-Milacic, Marija, 2017-02-06
dbId	8961961
displayName	E2F1 binds the CDC25A gene promoter
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
eventOf	[Pathway:R-HSA-69205] G1/S-Specific Transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-4088168] CDC25A gene [nucleoplasm] [Complex:R-HSA-68653] E2F1:TFDP1,TFDP2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:141354] Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [LiteratureReference:141377] CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E2F1 binds the CDC25A gene promoter
output	[Complex:R-HSA-8961960] E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21
revised	[InstanceEdit:617365] Matthews, L, 2010-04-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8961961
summation	[Summation:8961959] E2F1 binds to E2F binding sites in the promoter of the CDC25...

Referrals

(hasEvent)	[Pathway:R-HSA-69205] G1/S-Specific Transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex

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