Reactome | Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes

Schema > Reaction > Entries

Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes Show undefined attributes

catalystActivity	[CatalystActivity:10333692] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10333710
displayName	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
eventOf	[Pathway:R-BTA-69231] Cyclin D associated events in G1 - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-113503] PP2A mediated localization of RB1 protein in chromatin - Bos taurus [Reaction:R-BTA-188386] Association of Rb with Cyclin E:Cdk2 complexes - Bos taurus
inferredFrom	[Reaction:R-HSA-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-68642] RB1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-9687336] phospho-RB1 [nucleoplasm]
precedingEvent	[Reaction:R-BTA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Bos taurus [BlackBoxEvent:R-BTA-9659820] RB1 translocates to the nucleus - Bos taurus
regulatedBy	[NegativeRegulation:10333711] Negative regulation by 'p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm]' [NegativeRegulation:10333712] Negative regulation by 'p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-69227
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-BTA-113503] PP2A mediated localization of RB1 protein in chromatin [Reaction:R-BTA-188386] Association of Rb with Cyclin E:Cdk2 complexes
(hasEvent)	[Pathway:R-BTA-69231] Cyclin D associated events in G1
(inferredTo)	[Reaction:R-HSA-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes

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